Multimarker Screening of Oxidative Stress in Aging
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897435" target="_blank" >RIV/60461373:22310/14:43897435 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1155/2014/562860" target="_blank" >http://dx.doi.org/10.1155/2014/562860</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/562860" target="_blank" >10.1155/2014/562860</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Multimarker Screening of Oxidative Stress in Aging
Popis výsledku v původním jazyce
Aging is a complex process of organism decline in physiological functions. There is no clear theory explaining this phenomenon, but the most accepted one is the oxidative stress theory of aging. Biomarkers of oxidative stress, substances, which are formed during oxidative damage of phospholipids, proteins, and nucleic acids, are present in body fluids of diseased people as well as the healthy ones (in a physiological concentration). 8-iso prostaglandin F2? is themost prominent biomarker of phospholipidoxidative damage, o-tyrosine, 3-chlorotyrosine, and 3-nitrotyrosine are biomarkers of protein oxidative damage, and 8-hydroxy-2?-deoxyguanosine and 8-hydroxyguanosine are biomarkers of oxidative damage of nucleic acids. It is thought that the concentration of biomarkers increases as the age of people increases. However, the concentration of biomarkers in body fluids is very low and, therefore, it is necessary to use a sensitive analytical method. A combination of HPLC andMS was chosen to
Název v anglickém jazyce
Multimarker Screening of Oxidative Stress in Aging
Popis výsledku anglicky
Aging is a complex process of organism decline in physiological functions. There is no clear theory explaining this phenomenon, but the most accepted one is the oxidative stress theory of aging. Biomarkers of oxidative stress, substances, which are formed during oxidative damage of phospholipids, proteins, and nucleic acids, are present in body fluids of diseased people as well as the healthy ones (in a physiological concentration). 8-iso prostaglandin F2? is themost prominent biomarker of phospholipidoxidative damage, o-tyrosine, 3-chlorotyrosine, and 3-nitrotyrosine are biomarkers of protein oxidative damage, and 8-hydroxy-2?-deoxyguanosine and 8-hydroxyguanosine are biomarkers of oxidative damage of nucleic acids. It is thought that the concentration of biomarkers increases as the age of people increases. However, the concentration of biomarkers in body fluids is very low and, therefore, it is necessary to use a sensitive analytical method. A combination of HPLC andMS was chosen to
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CB - Analytická chemie, separace
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Oxidative Medicine and Cellular Longevity
ISSN
1942-0994
e-ISSN
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Svazek periodika
2014
Číslo periodika v rámci svazku
ID 562860
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
14
Strana od-do
1-14
Kód UT WoS článku
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EID výsledku v databázi Scopus
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