Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/60461373:22340/14:43897697

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate

Popis výsledku v původním jazyce

The objective of this study was to investigate the effect of different type of formulation (solid dispersion and physical mixture) with a poorly soluble active pharmaceutical ingredient (API) on water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate of the API. X-ray diffraction, Scanning Electron Microscopy, moisture sorption analysis, infrared (IR) spectroscopy and ATR-FTIR Imaging during dissolution were performed on API-polymer system (Aprepitant-PVP). The amorphous solid dispersion was prepared by spray drying. The interactions between the API and polymer molecules caused the water sorption isotherms of solid dispersions to deviate from those of ideal mixtures. The moisture sorption isotherm waslower in comparison with the isotherms of physical mixtures. The nature of the API-polymer interaction was explained by shifts in the characteristic bands of the IR spectra of the solid dispersions compared to the pure components. The dis

Název v anglickém jazyce

Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate

Popis výsledku anglicky

The objective of this study was to investigate the effect of different type of formulation (solid dispersion and physical mixture) with a poorly soluble active pharmaceutical ingredient (API) on water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate of the API. X-ray diffraction, Scanning Electron Microscopy, moisture sorption analysis, infrared (IR) spectroscopy and ATR-FTIR Imaging during dissolution were performed on API-polymer system (Aprepitant-PVP). The amorphous solid dispersion was prepared by spray drying. The interactions between the API and polymer molecules caused the water sorption isotherms of solid dispersions to deviate from those of ideal mixtures. The moisture sorption isotherm waslower in comparison with the isotherms of physical mixtures. The nature of the API-polymer interaction was explained by shifts in the characteristic bands of the IR spectra of the solid dispersions compared to the pure components. The dis

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering

ISBN

978-80-89475-13-1

ISSN

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e-ISSN

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Počet stran výsledku

10

Strana od-do

397-406

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare

Datum konání akce

26. 5. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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