A STUDY OF DISSOLUTION AND STABILITY KINETICS OF SOLID DOSAGE FORM PREPARED BY HOT-MELT EXTRUSION

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900717" target="_blank" >RIV/60461373:22310/15:43900717 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.icct.cz/2015/Full_Papers_ICCT_2015.pdf" target="_blank" >http://www.icct.cz/2015/Full_Papers_ICCT_2015.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A STUDY OF DISSOLUTION AND STABILITY KINETICS OF SOLID DOSAGE FORM PREPARED BY HOT-MELT EXTRUSION

Popis výsledku v původním jazyce

The work is focused on the preparation of solid dispersion in order to prepare solid solution. Solid dispersions were prepared using hot-melt extrusion. Characterization of solid dispersions was performed by X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). The stability of solid dispersions was also studied and was characterized by XRPD. The dissolution rate was studied by the flow-through cell apparatus (USP 4). It was prepared 5 mixtures of different composition API/ polymer. As a model drug Paracetamol and Phenylephrine hydrochloride or both of them in the mixture were chosen. Kollidon(R) VA64 was used as polymer. The only composition resulting to solid solution by hot-melt extrusion technique was that with higher contentof polymer (66,7 % polymer, 33,3 % API/ both APIs). From the dissolution experiments it was found that the initial dissolution rate is greatly affected by wetting the sample and the distribution of particle size in the sample. The modifi

Název v anglickém jazyce

A STUDY OF DISSOLUTION AND STABILITY KINETICS OF SOLID DOSAGE FORM PREPARED BY HOT-MELT EXTRUSION

Popis výsledku anglicky

The work is focused on the preparation of solid dispersion in order to prepare solid solution. Solid dispersions were prepared using hot-melt extrusion. Characterization of solid dispersions was performed by X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). The stability of solid dispersions was also studied and was characterized by XRPD. The dissolution rate was studied by the flow-through cell apparatus (USP 4). It was prepared 5 mixtures of different composition API/ polymer. As a model drug Paracetamol and Phenylephrine hydrochloride or both of them in the mixture were chosen. Kollidon(R) VA64 was used as polymer. The only composition resulting to solid solution by hot-melt extrusion technique was that with higher contentof polymer (66,7 % polymer, 33,3 % API/ both APIs). From the dissolution experiments it was found that the initial dissolution rate is greatly affected by wetting the sample and the distribution of particle size in the sample. The modifi

Druh

D - Stať ve sborníku

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 3rd International Conference on Chemical Technology

ISBN

978-80-86238-79-1

ISSN

2336-811X

e-ISSN

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Počet stran výsledku

5

Strana od-do

484-488

Název nakladatele

Česká společnost průmyslové chemie (ČSPCH)

Místo vydání

Praha

Místo konání akce

Mikulov

Datum konání akce

13. 4. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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