Increasing dissolution of trospium chloride by co-crystallization with urea

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897874" target="_blank" >RIV/60461373:22310/14:43897874 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcrysgro.2014.04.018" target="_blank" >http://dx.doi.org/10.1016/j.jcrysgro.2014.04.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcrysgro.2014.04.018" target="_blank" >10.1016/j.jcrysgro.2014.04.018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increasing dissolution of trospium chloride by co-crystallization with urea

Popis výsledku v původním jazyce

The search for various solid forms of an active pharmaceutical ingredient (API) is an important step in drug development. Our aim was to prepare co-crystals of trospium chloride, an anticholinergic drug used for the treatment of incontinence, and to investigate if they have advantageous properties for drug formulation. Phase identification was done by powder X-ray diffraction and single-crystal X-ray diffraction. The chemical composition was verified by solution NMR and the dissolution rate of the prepared phases was studied by IDR (intrinsic dissolution rate). For further analysis of phase stability and transitions, combined thermal analysis and temperature-resolved X-ray powder diffraction were used. Urea was selected as a co-crystallization partner.Trospium chloride urea (1:1) co-crystal was prepared by a solvent evaporation. from single-crystal data, the co-crystal structure was solved in a space group P2(1)/c and compared to previously published structures of trospium chloride. I

Název v anglickém jazyce

Increasing dissolution of trospium chloride by co-crystallization with urea

Popis výsledku anglicky

The search for various solid forms of an active pharmaceutical ingredient (API) is an important step in drug development. Our aim was to prepare co-crystals of trospium chloride, an anticholinergic drug used for the treatment of incontinence, and to investigate if they have advantageous properties for drug formulation. Phase identification was done by powder X-ray diffraction and single-crystal X-ray diffraction. The chemical composition was verified by solution NMR and the dissolution rate of the prepared phases was studied by IDR (intrinsic dissolution rate). For further analysis of phase stability and transitions, combined thermal analysis and temperature-resolved X-ray powder diffraction were used. Urea was selected as a co-crystallization partner.Trospium chloride urea (1:1) co-crystal was prepared by a solvent evaporation. from single-crystal data, the co-crystal structure was solved in a space group P2(1)/c and compared to previously published structures of trospium chloride. I

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA14-03636S" target="_blank" >GA14-03636S: Příprava a charakterizace pokročilých vícesložkových farmaceutických systémů s řízenými fyzikálně-chemickými vlastnostmi</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal Cryst.Growth

ISSN

0022-0248

e-ISSN

—

Svazek periodika

399

Číslo periodika v rámci svazku

AUG 1 2014

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

19-26

Kód UT WoS článku

000336432400004

EID výsledku v databázi Scopus

—