Trospium chloride: Unusual example of polymorphism based on structure disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F13%3A00425014" target="_blank" >RIV/68378271:_____/13:00425014 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/13:43895358

Výsledek na webu

<a href="http://dx.doi.org/10.1021/cg4007394" target="_blank" >http://dx.doi.org/10.1021/cg4007394</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/cg4007394" target="_blank" >10.1021/cg4007394</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Trospium chloride: Unusual example of polymorphism based on structure disorder

Popis výsledku v původním jazyce

The characterization of the solid state properties of an active pharmaceutical ingredient is a necessary step in drug development. One such API is trospium chloride, an anticholinergic drug used to treat incontinence and overactive bladder syndrome. Onecrystal form is known but, from the crystallographic point of view, has only been described by the X-ray powder diffraction pattern. Because, to the best of our knowledge, no crystal structures of trospium chloride have been published, we decided to prepare and describe different crystal forms. Using single-crystal X-ray diffraction, the structure s of two new polymorphs and of one unstable solvate were solved. All forms were obtained from ethanol mother liquor. Both polymorphs exhibited a significant pseudosymmetrical disorder. The polymorphs were highly similar but were distinguished by their symmetry and the resulting single-crystal diffraction behavior.

Název v anglickém jazyce

Trospium chloride: Unusual example of polymorphism based on structure disorder

Popis výsledku anglicky

The characterization of the solid state properties of an active pharmaceutical ingredient is a necessary step in drug development. One such API is trospium chloride, an anticholinergic drug used to treat incontinence and overactive bladder syndrome. Onecrystal form is known but, from the crystallographic point of view, has only been described by the X-ray powder diffraction pattern. Because, to the best of our knowledge, no crystal structures of trospium chloride have been published, we decided to prepare and describe different crystal forms. Using single-crystal X-ray diffraction, the structure s of two new polymorphs and of one unstable solvate were solved. All forms were obtained from ethanol mother liquor. Both polymorphs exhibited a significant pseudosymmetrical disorder. The polymorphs were highly similar but were distinguished by their symmetry and the resulting single-crystal diffraction behavior.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Crystal Growth & Design

ISSN

1528-7483

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

5193-5203

Kód UT WoS článku

000328100400008

EID výsledku v databázi Scopus

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