Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43898003" target="_blank" >RIV/60461373:22310/14:43898003 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/14:43898003 RIV/67985858:_____/14:00443176

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c4ra08385g" target="_blank" >http://dx.doi.org/10.1039/c4ra08385g</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c4ra08385g" target="_blank" >10.1039/c4ra08385g</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

Popis výsledku v původním jazyce

Light-activated antimicrobial materials based on polymethylmethacrylate doped with porphyrin and silver nanoparticles were prepared and studied. The inspiration for the material design originates from photodynamic therapy where light is used to destroy pathogen microbes. Antimicrobial response of the materials is controlled by blue light illumination. Porphyrin molecules serve as light absorbers with dual antimicrobial response under illumination they produce reactive oxygen and affect the kinetics of silver release from the polymer. Silver is responsive for the antimicrobial effect, for the protection of porphyrin against photobleaching and for the conservation of energy through suppression of porphyrin luminescence. Triggerable and enhanced antimicrobial response of the material is activated through several possible mechanisms, including local heating of the polymer matrix, transfer of the excited state from porphyrin to silver and the synergetic effect of reactive oxygen and silver. In a passive state the material exhibits weak antimicrobial response against Gram-negative bacteria. In an active state, however, it is fatal for both Gram negative and Gram positive bacteria.

Název v anglickém jazyce

Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

Popis výsledku anglicky

Light-activated antimicrobial materials based on polymethylmethacrylate doped with porphyrin and silver nanoparticles were prepared and studied. The inspiration for the material design originates from photodynamic therapy where light is used to destroy pathogen microbes. Antimicrobial response of the materials is controlled by blue light illumination. Porphyrin molecules serve as light absorbers with dual antimicrobial response under illumination they produce reactive oxygen and affect the kinetics of silver release from the polymer. Silver is responsive for the antimicrobial effect, for the protection of porphyrin against photobleaching and for the conservation of energy through suppression of porphyrin luminescence. Triggerable and enhanced antimicrobial response of the material is activated through several possible mechanisms, including local heating of the polymer matrix, transfer of the excited state from porphyrin to silver and the synergetic effect of reactive oxygen and silver. In a passive state the material exhibits weak antimicrobial response against Gram-negative bacteria. In an active state, however, it is fatal for both Gram negative and Gram positive bacteria.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

—

Projekt

<a href="/cs/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Příprava, modifikace a charakterizace materiálů zářením</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

92

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

50624-50630

Kód UT WoS článku

000344325400040

EID výsledku v databázi Scopus

—