Smart metal nanostructures for effective bacterial inhibition

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F16%3A43902616" target="_blank" >RIV/60461373:22310/16:43902616 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Smart metal nanostructures for effective bacterial inhibition

Popis výsledku v původním jazyce

The increasing resistance of pathogenic bacteria to conventional antibiotics is a major problem of public health in the second half of this century. Therefore, it is exceptionally desired to search non-conventional antimicrobial agents able to inhibit microbial growth. This chapter provides comprehensive overview on smart materials based on structured noble metals covering its various forms from ultrathin layers over discrete metal islands up to isolated nanoparticles having exceptional properties applicable in prevention of bacterial infections. The type of underlaying substrate, forming the support for active metal nanostructure, was carefully chosen to match the specific application of individual composites (organic polymer fibers and layers, artificial polymer foils). Engineered antimicrobial materials are tested on vast range of microorganisms of Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. First subsection of the chapter is devoted to overview on antibacterial activity of Ag and Pd nanostructures prepared by DC sputtering on polymeric foils (PI, PEN) of great medical-care importance. The possibility of managing nanostructure size via controlling the thickness of metal nanolayers prior to their annealing is considered. Antibacterial properties of such metal/polymer composites are evaluated by a drip test using Gram-positive and Gram-negative bacteria. Significant differences between antibacterial response of Ag/PI and Pd/PEN is revealed. Secondly, the system of polymer/metal composites with triggerable activity is discussed and some examples of such systems are introduced. As external stimuli the pH, temperature or light is used to activate antimicrobial activity.

Název v anglickém jazyce

Smart metal nanostructures for effective bacterial inhibition

Popis výsledku anglicky

The increasing resistance of pathogenic bacteria to conventional antibiotics is a major problem of public health in the second half of this century. Therefore, it is exceptionally desired to search non-conventional antimicrobial agents able to inhibit microbial growth. This chapter provides comprehensive overview on smart materials based on structured noble metals covering its various forms from ultrathin layers over discrete metal islands up to isolated nanoparticles having exceptional properties applicable in prevention of bacterial infections. The type of underlaying substrate, forming the support for active metal nanostructure, was carefully chosen to match the specific application of individual composites (organic polymer fibers and layers, artificial polymer foils). Engineered antimicrobial materials are tested on vast range of microorganisms of Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. First subsection of the chapter is devoted to overview on antibacterial activity of Ag and Pd nanostructures prepared by DC sputtering on polymeric foils (PI, PEN) of great medical-care importance. The possibility of managing nanostructure size via controlling the thickness of metal nanolayers prior to their annealing is considered. Antibacterial properties of such metal/polymer composites are evaluated by a drip test using Gram-positive and Gram-negative bacteria. Significant differences between antibacterial response of Ag/PI and Pd/PEN is revealed. Secondly, the system of polymer/metal composites with triggerable activity is discussed and some examples of such systems are introduced. As external stimuli the pH, temperature or light is used to activate antimicrobial activity.

Druh

C - Kapitola v odborné knize

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Antibacterials: Synthesis, Properties and Biological Activities

ISBN

978-1-63485-793-2

Počet stran výsledku

42

Strana od-do

27-68

Počet stran knihy

271

Název nakladatele

Nova Science Publishers, Inc.

Místo vydání

New York

Kód UT WoS kapitoly

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