Biocompatibility of modified Ultra high molecular weight polyethylene

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F16%3A43902711" target="_blank" >RIV/60461373:22310/16:43902711 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/16:43902711

Výsledek na webu

<a href="http://dx.doi.org/10.1117/12.2237379" target="_blank" >http://dx.doi.org/10.1117/12.2237379</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1117/12.2237379" target="_blank" >10.1117/12.2237379</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biocompatibility of modified Ultra high molecular weight polyethylene

Popis výsledku v původním jazyce

Ultra-high-molecular-weight polyethylene (UHMWPE, PE) is a synthetic polymer used for biomedical applications because of its high impact resistance, ductility and stability in contact with physiological fluids. Therefore this material is being used in human orthopedic implants such as total joint replacements. Surface modification of this material relates to changes of its surface hydrophilicity, energy, microstructure, roughness, and morphology, all influencing its biological response. In our recent work, PE was treated by an Ar+ plasma discharge and then grafted with biologically active polyethylene glycol in order to enhance adhesion and proliferation of mouse fibroblast (L929). The surface properties of pristine PE and its grafted counterparts were studied by goniometry (surface wettability). Furthermore, Atomic Force Microscopy was used to determine the surface morphology and roughness. The biological response of the L929 cell lines seeded on untreated and plasma treated PE matrices was quantified in terms of the cell adhesion, density, and metabolic activity.

Název v anglickém jazyce

Biocompatibility of modified Ultra high molecular weight polyethylene

Popis výsledku anglicky

Ultra-high-molecular-weight polyethylene (UHMWPE, PE) is a synthetic polymer used for biomedical applications because of its high impact resistance, ductility and stability in contact with physiological fluids. Therefore this material is being used in human orthopedic implants such as total joint replacements. Surface modification of this material relates to changes of its surface hydrophilicity, energy, microstructure, roughness, and morphology, all influencing its biological response. In our recent work, PE was treated by an Ar+ plasma discharge and then grafted with biologically active polyethylene glycol in order to enhance adhesion and proliferation of mouse fibroblast (L929). The surface properties of pristine PE and its grafted counterparts were studied by goniometry (surface wettability). Furthermore, Atomic Force Microscopy was used to determine the surface morphology and roughness. The biological response of the L929 cell lines seeded on untreated and plasma treated PE matrices was quantified in terms of the cell adhesion, density, and metabolic activity.

Druh

D - Stať ve sborníku

CEP obor

JJ - Ostatní materiály

OECD FORD obor

—

Projekt

<a href="/cs/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Příprava, modifikace a charakterizace materiálů zářením</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of SPIE Volume 9930 BIOSENSING AND NANOMEDICINE IX

ISBN

978-1-5106-0251-9

ISSN

—

e-ISSN

—

Počet stran výsledku

7

Strana od-do

"UNSP 99300Y"

Název nakladatele

SPIE the International Society for Optical Engineering

Místo vydání

Bellingham, WA

Místo konání akce

San Diego

Datum konání akce

28. 8. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000389681300022