EFFECT OF MAGNESIUM ALUMINOSILICATE MATERIALS ON FLOW PROPERTIES OF PHARMACEUTICAL EXCIPIENTS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916368" target="_blank" >RIV/60461373:22310/18:43916368 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf" target="_blank" >https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EFFECT OF MAGNESIUM ALUMINOSILICATE MATERIALS ON FLOW PROPERTIES OF PHARMACEUTICAL EXCIPIENTS

Popis výsledku v původním jazyce

Flow properties are one of the most important characteristics of pharmaceutical powder blends due to their influence on the content and weight uniformity of the final product – tablets or capsules. In view of the fact that flow properties depend on various factors such as particle size, particle size distribution, particle shape, moisture and electrical charge, optimizing flow properties of pharmaceutical powders is generally difficult. In order to improve flowability of particles, flow enhancers or glidants are widely incorporated in solid dosage forms. Traditional glidants are surface-active particles and their action is very sensitive to formulation and process parameters of the mixing operation. This work is focused on studying the mechanism of improving flow properties of pharmaceutical excipients using novel family of glidants - magnesium aluminosilicate materials (MAS). These materials are characterized by very low cohesive interactions. As a result, using MAS could avoid the disadvantages of using conventional glidants. Several blends comprising the model excipient and MAS were prepared and their flow properties characterized using a powder rheometer FT4 (Freemantech, UK). The blends were formulated to represent the effects of particle size, MAS loading, and mixing time. After pre-conditioning, the flow properties were measured using shear test, compressibility, and flow energy measurements. All studied parameters were found to have substantial effects on flow properties of powder blends, but the effect of mixing time was much less important compared to the mixtures based on traditional glidants. The mechanism of MAS glidant action was found to be different compared to other glidants, having less process sensitivity, so that MAS utilization as glidant could be advantageous for the formulation performance.

Název v anglickém jazyce

EFFECT OF MAGNESIUM ALUMINOSILICATE MATERIALS ON FLOW PROPERTIES OF PHARMACEUTICAL EXCIPIENTS

Popis výsledku anglicky

Flow properties are one of the most important characteristics of pharmaceutical powder blends due to their influence on the content and weight uniformity of the final product – tablets or capsules. In view of the fact that flow properties depend on various factors such as particle size, particle size distribution, particle shape, moisture and electrical charge, optimizing flow properties of pharmaceutical powders is generally difficult. In order to improve flowability of particles, flow enhancers or glidants are widely incorporated in solid dosage forms. Traditional glidants are surface-active particles and their action is very sensitive to formulation and process parameters of the mixing operation. This work is focused on studying the mechanism of improving flow properties of pharmaceutical excipients using novel family of glidants - magnesium aluminosilicate materials (MAS). These materials are characterized by very low cohesive interactions. As a result, using MAS could avoid the disadvantages of using conventional glidants. Several blends comprising the model excipient and MAS were prepared and their flow properties characterized using a powder rheometer FT4 (Freemantech, UK). The blends were formulated to represent the effects of particle size, MAS loading, and mixing time. After pre-conditioning, the flow properties were measured using shear test, compressibility, and flow energy measurements. All studied parameters were found to have substantial effects on flow properties of powder blends, but the effect of mixing time was much less important compared to the mixtures based on traditional glidants. The mechanism of MAS glidant action was found to be different compared to other glidants, having less process sensitivity, so that MAS utilization as glidant could be advantageous for the formulation performance.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PROCEEDINGS of the 6th International Conference on Chemical Technology

ISBN

978-80-86238-77-7

ISSN

2336-8128

e-ISSN

2336-8128

Počet stran výsledku

5

Strana od-do

380-384

Název nakladatele

Česká společnost průmyslové chemie (ČSPCH)

Místo vydání

Praha

Místo konání akce

Mikulov

Datum konání akce

16. 4. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000461293800070