IMPACT OF COMPRESSION PRESSURE ON PHARMACEUTICAL FORMULATIONS CONTAINING MAGNESIUM ALUMINOMETASILICATES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43920063" target="_blank" >RIV/60461373:22310/19:43920063 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.researchgate.net/profile/Pavlina_Kominova/publications" target="_blank" >https://www.researchgate.net/profile/Pavlina_Kominova/publications</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

IMPACT OF COMPRESSION PRESSURE ON PHARMACEUTICAL FORMULATIONS CONTAINING MAGNESIUM ALUMINOMETASILICATES

Popis výsledku v původním jazyce

In pharmaceutical industry, free flow behaviour of powders is a precondition for an unproblematic production process and final product quality for e.g. capsules and tablets. Flow properties of powders can be improved significantly by the addition of small amount of glidants that diminish attractive forces among particles. Based on our previous research focused on the character of novel glidant family - magnesium aluminometasilicates (MAS), repulsive character of their particles was observed in case of very low pressure conditions (free flow powder) and corresponded to their glidant effect. However, the predisposition to form particle interactions between the MAS particles and between MAS and the other excipient particle appeared at applied high pressures (tablet formed). Therefore, the intention of this study was to characterize behaviour of powder mixtures containing MAS during their exposure to different pressures. Results revealed MAS particles retained their repulsive character and small contact surface area under normal conditions. If threshold pressure is applied, the destruction of MAS particles and formation of new surfaces leading to particle interactions are observed. Ability of MAS particles to form interactions intensifies with increasing pressure. This &quot;function switching&quot; makes the MAS materials suitable for using as multifunctional excipients in direct tablet compression when they act as a glidant or a binder depending on applied pressure.

Název v anglickém jazyce

IMPACT OF COMPRESSION PRESSURE ON PHARMACEUTICAL FORMULATIONS CONTAINING MAGNESIUM ALUMINOMETASILICATES

Popis výsledku anglicky

In pharmaceutical industry, free flow behaviour of powders is a precondition for an unproblematic production process and final product quality for e.g. capsules and tablets. Flow properties of powders can be improved significantly by the addition of small amount of glidants that diminish attractive forces among particles. Based on our previous research focused on the character of novel glidant family - magnesium aluminometasilicates (MAS), repulsive character of their particles was observed in case of very low pressure conditions (free flow powder) and corresponded to their glidant effect. However, the predisposition to form particle interactions between the MAS particles and between MAS and the other excipient particle appeared at applied high pressures (tablet formed). Therefore, the intention of this study was to characterize behaviour of powder mixtures containing MAS during their exposure to different pressures. Results revealed MAS particles retained their repulsive character and small contact surface area under normal conditions. If threshold pressure is applied, the destruction of MAS particles and formation of new surfaces leading to particle interactions are observed. Ability of MAS particles to form interactions intensifies with increasing pressure. This &quot;function switching&quot; makes the MAS materials suitable for using as multifunctional excipients in direct tablet compression when they act as a glidant or a binder depending on applied pressure.

Druh

A - Audiovizuální tvorba

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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