Measurement of the particulate interactions in binary mixtures using energy balance of the surface energy obtained by IGC

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916751" target="_blank" >RIV/60461373:22310/18:43916751 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf" target="_blank" >https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Measurement of the particulate interactions in binary mixtures using energy balance of the surface energy obtained by IGC

Popis výsledku v původním jazyce

The study was focused on the measurement of interactions between the components in the binary mixtures in terms of energy balance based on surface free energy and its dispersive and/or specific components. The binary mixtures were prepared in the various ratios of poorly water-soluble Tadalafil and carriers, i.e. Kollidon® 12 PF, Kollidon® VA 64, Parteck® MXP, or Soluplus® which are widely used in the solid dispersions, and Parteck® M DPI which can be used in dry powder inhalers. Inverse gas chromatography (IGC) was used to assess the surface parameters. The results indicate that energy analysis of binary mixtures obtained by IGC allows to predict the preferred interactions between the components (i.e. drug-excipient interactions) or whether the surface energy is utilized in another way (e.g. to form the particle agglomerates of one component) and therefore, the components do not interact. The works of adhesion and cohesion were also determined.

Název v anglickém jazyce

Measurement of the particulate interactions in binary mixtures using energy balance of the surface energy obtained by IGC

Popis výsledku anglicky

The study was focused on the measurement of interactions between the components in the binary mixtures in terms of energy balance based on surface free energy and its dispersive and/or specific components. The binary mixtures were prepared in the various ratios of poorly water-soluble Tadalafil and carriers, i.e. Kollidon® 12 PF, Kollidon® VA 64, Parteck® MXP, or Soluplus® which are widely used in the solid dispersions, and Parteck® M DPI which can be used in dry powder inhalers. Inverse gas chromatography (IGC) was used to assess the surface parameters. The results indicate that energy analysis of binary mixtures obtained by IGC allows to predict the preferred interactions between the components (i.e. drug-excipient interactions) or whether the surface energy is utilized in another way (e.g. to form the particle agglomerates of one component) and therefore, the components do not interact. The works of adhesion and cohesion were also determined.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LO1613" target="_blank" >LO1613: Výzkum nových materiálů pro chemický průmysl</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PROCEEDINGS of the 6th International Conference on Chemical Technology

ISBN

978-80-86238-77-7

ISSN

2336-8128

e-ISSN

2336-8128

Počet stran výsledku

5

Strana od-do

375-379

Název nakladatele

Česká společnost průmyslové chemie (ČSPCH)

Místo vydání

Praha

Místo konání akce

Mikulov

Datum konání akce

16. 4. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000461293800069