PREDICTING INTERACTIVE MIXTURE STABILITY USING PARTICLE ADHESION MEASUREMENT BY CENTRIFUGING/IMAGE ANALYSIS
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43919621" target="_blank" >RIV/60461373:22310/19:43919621 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf" target="_blank" >https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
PREDICTING INTERACTIVE MIXTURE STABILITY USING PARTICLE ADHESION MEASUREMENT BY CENTRIFUGING/IMAGE ANALYSIS
Popis výsledku v původním jazyce
An interactive mixture, i.e. a blend of larger carrier particles with active pharmaceutical ingredient (API) particles adhered on their surfaces, is often used in pharmaceutical formulations for promoting powder flow, improving blend uniformity, reducing the segregation risk during manipulation, and improving the solubility of poorly water-soluble APIs. Obtaining uniform and stable interactive mixtures require adhesion forces between fine API and coarse carrier particles to exceed the cohesion forces between API particles.This work was aimed at developing the methodology measuring the particle adhesion by centrifugation combined with the optical microscopy to predict interactions between components in mixtures. Comparing our results to the results of interactive force measurement based on surface energy for the same analysed systems of excipients (Kollidon® VA64, Kollidon® 12, Soluplus®) and tadalafil, using centrifuge technique may overcome all the limitations of employing the atomic force microscopy (AFM) and inverse gas chromatography (IGC) for adhesion measurement.
Název v anglickém jazyce
PREDICTING INTERACTIVE MIXTURE STABILITY USING PARTICLE ADHESION MEASUREMENT BY CENTRIFUGING/IMAGE ANALYSIS
Popis výsledku anglicky
An interactive mixture, i.e. a blend of larger carrier particles with active pharmaceutical ingredient (API) particles adhered on their surfaces, is often used in pharmaceutical formulations for promoting powder flow, improving blend uniformity, reducing the segregation risk during manipulation, and improving the solubility of poorly water-soluble APIs. Obtaining uniform and stable interactive mixtures require adhesion forces between fine API and coarse carrier particles to exceed the cohesion forces between API particles.This work was aimed at developing the methodology measuring the particle adhesion by centrifugation combined with the optical microscopy to predict interactions between components in mixtures. Comparing our results to the results of interactive force measurement based on surface energy for the same analysed systems of excipients (Kollidon® VA64, Kollidon® 12, Soluplus®) and tadalafil, using centrifuge technique may overcome all the limitations of employing the atomic force microscopy (AFM) and inverse gas chromatography (IGC) for adhesion measurement.
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
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OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
Proceedings of the 7th International Conference on Chemical Technology
ISBN
978-80-88307-00-6
ISSN
2336-811X
e-ISSN
2336-8128
Počet stran výsledku
6
Strana od-do
275-280
Název nakladatele
Czech Society of Industrial Chemistry
Místo vydání
Prague
Místo konání akce
Mikulov
Datum konání akce
15. 4. 2019
Typ akce podle státní příslušnosti
WRD - Celosvětová akce
Kód UT WoS článku
000515696600050