ADHESION FORCE MEASUREMENT BY CENTRIFUGE TECHNIQUE AS TOOL FOR PREDICTING INTERACTIVE MIXTURE STABILITY

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43920068" target="_blank" >RIV/60461373:22310/19:43920068 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sheffield.ac.uk/agglom/2019" target="_blank" >https://www.sheffield.ac.uk/agglom/2019</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

ADHESION FORCE MEASUREMENT BY CENTRIFUGE TECHNIQUE AS TOOL FOR PREDICTING INTERACTIVE MIXTURE STABILITY

Popis výsledku v původním jazyce

The use of interactive mixtures is one of methods, how to achieve acceptable bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Fixing the API on the surface of larger excipient particles by forming the interactive mixture enables large surface area being available for the dissolution. Adhesion forces between API particles and coarse carrier particles should exceed cohesive forces between fine API particles in order to obtain uniform and stable interactive mixtures. Therefore, the aim of this study was to verify the adhesion force measurement as a tool for predicting interactive mixture stability. In this work, the centrifugal technique, based on the particle detachment from a surface due to centrifugal force, was used to measure particle adhesion force distribution. Experiments were carried out by repeated exposure of a system of deposited particles on a carrier surface by centrifugation, at a progressively increasing rotation speed, and thus by the increasing centrifugal force acting on the particles. In the pilot phase, excipient particles were chosen as model substances, both for the preparation of the carrier surface and deposited particles. As expected, the developed methodology for measuring the adhesion force by centrifugation method in combination with optical microscopy was able to demonstrate how surface texture affects adhesive interactions. Results showed that the key factor influencing adhesion in system deposited particle - carrier surface can be the real contact area. It seemed that the larger the real contact surface, the stronger the interaction created in this system and thus greater forces would be required to detach particles from the carrier surface.

Název v anglickém jazyce

ADHESION FORCE MEASUREMENT BY CENTRIFUGE TECHNIQUE AS TOOL FOR PREDICTING INTERACTIVE MIXTURE STABILITY

Popis výsledku anglicky

The use of interactive mixtures is one of methods, how to achieve acceptable bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Fixing the API on the surface of larger excipient particles by forming the interactive mixture enables large surface area being available for the dissolution. Adhesion forces between API particles and coarse carrier particles should exceed cohesive forces between fine API particles in order to obtain uniform and stable interactive mixtures. Therefore, the aim of this study was to verify the adhesion force measurement as a tool for predicting interactive mixture stability. In this work, the centrifugal technique, based on the particle detachment from a surface due to centrifugal force, was used to measure particle adhesion force distribution. Experiments were carried out by repeated exposure of a system of deposited particles on a carrier surface by centrifugation, at a progressively increasing rotation speed, and thus by the increasing centrifugal force acting on the particles. In the pilot phase, excipient particles were chosen as model substances, both for the preparation of the carrier surface and deposited particles. As expected, the developed methodology for measuring the adhesion force by centrifugation method in combination with optical microscopy was able to demonstrate how surface texture affects adhesive interactions. Results showed that the key factor influencing adhesion in system deposited particle - carrier surface can be the real contact area. It seemed that the larger the real contact surface, the stronger the interaction created in this system and thus greater forces would be required to detach particles from the carrier surface.

Druh

A - Audiovizuální tvorba

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Místo vydání

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Název nakladatele resp. objednatele

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Verze

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Identifikační číslo nosiče

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