Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43925899" target="_blank" >RIV/60461373:22310/22:43925899 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/22:10451086

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0378517322007529?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517322007529?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2022.122198" target="_blank" >10.1016/j.ijpharm.2022.122198</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity?

Popis výsledku v původním jazyce

The aim of this work is to contribute to the theoretical investigation of cohesive powder surface properties regarding the surface energy both in a qualitative and quantitative way. The relationship between cohesion (shear testing), the energy to break avalanche (avalanche testing) and the surface energy heterogeneity (inverse gas chromatography, IGC) was investigated using binary mixtures of the cohesive drug meloxicam (M) in a range of 5–50% (w/w) and excipients, i.e., alginic acid (AA) and calcium alginate (AC), prepared by mixing and co-milling. A linear relationship was detected between the cohesion and energy to break an avalanche (R2 = 0.633) and the cohesion and specific surface area of the powders (R2 = 0.862). The surface energy heterogeneity measurement at a nominal surface coverage 0.04–0.10 allowed to compare the experimentally estimated work of cohesion (showing the cohesive interaction between the particles) with the theoretical estimation of work of adhesion between a drug and the host carrier. The preference of adhesive forces with the carrier materials was demonstrated in case of M. Better adhesion properties of AA were observed together with the highest dispersive energy, while interestingly, the lowest value of cohesion was also noted for this excipient.

Název v anglickém jazyce

Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity?

Popis výsledku anglicky

The aim of this work is to contribute to the theoretical investigation of cohesive powder surface properties regarding the surface energy both in a qualitative and quantitative way. The relationship between cohesion (shear testing), the energy to break avalanche (avalanche testing) and the surface energy heterogeneity (inverse gas chromatography, IGC) was investigated using binary mixtures of the cohesive drug meloxicam (M) in a range of 5–50% (w/w) and excipients, i.e., alginic acid (AA) and calcium alginate (AC), prepared by mixing and co-milling. A linear relationship was detected between the cohesion and energy to break an avalanche (R2 = 0.633) and the cohesion and specific surface area of the powders (R2 = 0.862). The surface energy heterogeneity measurement at a nominal surface coverage 0.04–0.10 allowed to compare the experimentally estimated work of cohesion (showing the cohesive interaction between the particles) with the theoretical estimation of work of adhesion between a drug and the host carrier. The preference of adhesive forces with the carrier materials was demonstrated in case of M. Better adhesion properties of AA were observed together with the highest dispersive energy, while interestingly, the lowest value of cohesion was also noted for this excipient.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Pharmaceutics

ISSN

0378-5173

e-ISSN

1873-3476

Svazek periodika

626

Číslo periodika v rámci svazku

122198

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

nestrankovano

Kód UT WoS článku

000869411700009

EID výsledku v databázi Scopus

2-s2.0-85138837057