Adhesion force measurement by centrifuge technique as tool for predicting interactive mixture stability

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43920577" target="_blank" >RIV/60461373:22310/21:43920577 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0263876220305189?dgcid=rss_sd_all" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0263876220305189?dgcid=rss_sd_all</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cherd.2020.10.012" target="_blank" >10.1016/j.cherd.2020.10.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adhesion force measurement by centrifuge technique as tool for predicting interactive mixture stability

Popis výsledku v původním jazyce

An interactive mixture, i.e. a blend of larger carrier particles with drug particles adhered on their surfaces, is often used in pharmaceutical formulations for promoting powder flow, improving blend uniformity, reducing the segregation risk during manipulation, and improving the solubility of poorly water-soluble drug. Obtaining uniform and stable interactive mixtures require adhesion forces between fine drug and coarse carrier particles to exceed the cohesion forces between drug particles. This work was aimed at developing the methodology measuring the particle adhesion by centrifugation combined with the optical microscopy to predict interactions between components in the mixtures. In the pilot phase, excipient particles were chosen as model substances, both for the preparation of the carrier surface and deposited particles. As expected, our developed methodology was able to map the behaviour of particles on the rugged surfaces and provide the adhesion strength distribution used for comparing different material adhesion. It can also provide a measure of interactive unit stability when the mixture undergoes process treatment characterised by certain mechanical stress. © 2020 Institution of Chemical Engineers

Název v anglickém jazyce

Adhesion force measurement by centrifuge technique as tool for predicting interactive mixture stability

Popis výsledku anglicky

An interactive mixture, i.e. a blend of larger carrier particles with drug particles adhered on their surfaces, is often used in pharmaceutical formulations for promoting powder flow, improving blend uniformity, reducing the segregation risk during manipulation, and improving the solubility of poorly water-soluble drug. Obtaining uniform and stable interactive mixtures require adhesion forces between fine drug and coarse carrier particles to exceed the cohesion forces between drug particles. This work was aimed at developing the methodology measuring the particle adhesion by centrifugation combined with the optical microscopy to predict interactions between components in the mixtures. In the pilot phase, excipient particles were chosen as model substances, both for the preparation of the carrier surface and deposited particles. As expected, our developed methodology was able to map the behaviour of particles on the rugged surfaces and provide the adhesion strength distribution used for comparing different material adhesion. It can also provide a measure of interactive unit stability when the mixture undergoes process treatment characterised by certain mechanical stress. © 2020 Institution of Chemical Engineers

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LO1613" target="_blank" >LO1613: Výzkum nových materiálů pro chemický průmysl</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Engineering Research and Design

ISSN

0263-8762

e-ISSN

—

Svazek periodika

165

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

SG - Singapurská republika

Počet stran výsledku

10

Strana od-do

467-476

Kód UT WoS článku

000615853600007

EID výsledku v databázi Scopus

2-s2.0-85094940896