Benzene IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 120

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43921041" target="_blank" >RIV/60461373:22310/18:43921041 - isvavai.cz</a>

Výsledek na webu

<a href="https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Benzene-2018" target="_blank" >https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Benzene-2018</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Benzene IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 120

Popis výsledku v původním jazyce

Benzene is carcinogenic to human (Group 1 carcinogen). There is sufficient evidence in humans for the carcinogenicity of benzene. Benzene causes acute myeloid leukaemia in adults. Positive associations have been observed for non-Hodgkin lymphoma, chronic lymphoid leukaemia, multiple myeloma, chronic myeloid leukaemia, acute myeloid leukaemia in children, and cancer of the lung. There is sufficient evidence in experimental animals for the carcinogenicity of benzene. A Group 1 evaluation was supported by mechanistic data demonstrating that benzene exhibits many of the key characteristics of carcinogens. In particular, there is strong evidence, including in exposed humans, that benzene: is metabolically activated to electrophilic metabolites; induces oxidative stress and associated oxidative DNA damage; is genotoxic, inducing DNA damage and chromosomal changes; is immunosuppressive; and causes haematotoxicity.

Název v anglickém jazyce

Benzene IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 120

Popis výsledku anglicky

Benzene is carcinogenic to human (Group 1 carcinogen). There is sufficient evidence in humans for the carcinogenicity of benzene. Benzene causes acute myeloid leukaemia in adults. Positive associations have been observed for non-Hodgkin lymphoma, chronic lymphoid leukaemia, multiple myeloma, chronic myeloid leukaemia, acute myeloid leukaemia in children, and cancer of the lung. There is sufficient evidence in experimental animals for the carcinogenicity of benzene. A Group 1 evaluation was supported by mechanistic data demonstrating that benzene exhibits many of the key characteristics of carcinogens. In particular, there is strong evidence, including in exposed humans, that benzene: is metabolically activated to electrophilic metabolites; induces oxidative stress and associated oxidative DNA damage; is genotoxic, inducing DNA damage and chromosomal changes; is immunosuppressive; and causes haematotoxicity.

Druh

B - Odborná kniha

CEP obor

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OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/2B08051" target="_blank" >2B08051: Nová strategie biologického monitorování exposice mutagenům a karcinogenům</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

978-92-832-0158-8

Počet stran knihy

300

Název nakladatele

IARC

Místo vydání

Lyon

Kód UT WoS knihy

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