Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F09%3A00347149" target="_blank" >RIV/68378050:_____/09:00347149 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

Popis výsledku v původním jazyce

Cytolethal distending toxins (CDT) are proteins produced and secreted by facultative pathogenic strains of gram-negative bacteria with potentially genotoxic effects. We found both normal and cancer human cells exposed to CDT, surviving the acute phase ofintoxication by Haemophilus ducreyi CDT, possess the main hallmarks of cellular senescence including persistently activated DNA damage signalling, expansion of promyelocytic leukaemia nuclear compartment and induced expression of several cytokines (e.g.IL-6, IL-8 and IL-24). We conclude that analogous to oncogenic, oxidative and replicative stresses, bacterial toxins represent another pathophysiological stimulus that induces premature senescence. Thus, the activation of cellular senescence as the anticancer barrier, together with evidence of chromosomal defects reported here, support the emerging genotoxic and potentially oncogenic effects of this group of bacterial toxins, and warrant further research of their role in human disease.

Název v anglickém jazyce

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

Popis výsledku anglicky

Cytolethal distending toxins (CDT) are proteins produced and secreted by facultative pathogenic strains of gram-negative bacteria with potentially genotoxic effects. We found both normal and cancer human cells exposed to CDT, surviving the acute phase ofintoxication by Haemophilus ducreyi CDT, possess the main hallmarks of cellular senescence including persistently activated DNA damage signalling, expansion of promyelocytic leukaemia nuclear compartment and induced expression of several cytokines (e.g.IL-6, IL-8 and IL-24). We conclude that analogous to oncogenic, oxidative and replicative stresses, bacterial toxins represent another pathophysiological stimulus that induces premature senescence. Thus, the activation of cellular senescence as the anticancer barrier, together with evidence of chromosomal defects reported here, support the emerging genotoxic and potentially oncogenic effects of this group of bacterial toxins, and warrant further research of their role in human disease.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cellular and Molecular Medicine

ISSN

1582-1838

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

000275639700031

EID výsledku v databázi Scopus

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