Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43918300" target="_blank" >RIV/60461373:22310/19:43918300 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216305:26620/19:PU136230
Výsledek na webu
<a href="https://www.journal.csj.jp/doi/10.1246/bcsj.20190104" target="_blank" >https://www.journal.csj.jp/doi/10.1246/bcsj.20190104</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1246/bcsj.20190104" target="_blank" >10.1246/bcsj.20190104</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells
Popis výsledku v původním jazyce
Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 mu g mL(-1), drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.
Název v anglickém jazyce
Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells
Popis výsledku anglicky
Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 mu g mL(-1), drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Bulletin of the Chemical Society of Japan
ISSN
0009-2673
e-ISSN
—
Svazek periodika
92
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
JP - Japonsko
Počet stran výsledku
5
Strana od-do
1754-1758
Kód UT WoS článku
000485218200013
EID výsledku v databázi Scopus
2-s2.0-85072645454