Trans-palladium complexes with 1-adamantanamine and various halide ions: Synthesis, characterization, DNA and protein binding and in vitro cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922363" target="_blank" >RIV/60461373:22310/21:43922363 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/21:43922363 RIV/60461373:22340/21:43922363

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S027753872100440X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S027753872100440X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.poly.2021.115458" target="_blank" >10.1016/j.poly.2021.115458</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Trans-palladium complexes with 1-adamantanamine and various halide ions: Synthesis, characterization, DNA and protein binding and in vitro cytotoxicity

Popis výsledku v původním jazyce

Research into the antitumor effects of transition metals has been devoted to the decades since the discovery of the cytostatic properties of the platinum complex cisplatin, which despite numerous side effects, is still one of the most prescribed cytostatics. A promising way to develop a new similar complex is to select a suitable ligand. An interesting group of ligands is diamantanoid derivatives, which, due to their high lipophilicity and bulk, show promising pharmacological properties. With this in mind, we have prepared three trans-palladium(II) complexes with bulky 1-adamantanamine and different halide ligands (chlorine, bromine and iodine). The complexes (1-3) were analytically characterized to confirm their structures by FT-IR, 1H and 13C NMR, HR-MS and XRD techniques for the first time. The interaction of DNA with complexes 1-3 was investigated and the affinity to DNA was confirmed by a DNA binding study, gel electrophoresis and electronic circular dichroism. A protein binding study was carried out and a weak interaction with proteins was found. Finally, the anticancer abilities of palladium complexes 1-3, compared to another cytostatic drug oxaliplatin, were tested and confirmed on the cancer cell lines RAW, HeLa, HOC and HL-60, and the healthy cell line MRC-5.

Název v anglickém jazyce

Trans-palladium complexes with 1-adamantanamine and various halide ions: Synthesis, characterization, DNA and protein binding and in vitro cytotoxicity

Popis výsledku anglicky

Research into the antitumor effects of transition metals has been devoted to the decades since the discovery of the cytostatic properties of the platinum complex cisplatin, which despite numerous side effects, is still one of the most prescribed cytostatics. A promising way to develop a new similar complex is to select a suitable ligand. An interesting group of ligands is diamantanoid derivatives, which, due to their high lipophilicity and bulk, show promising pharmacological properties. With this in mind, we have prepared three trans-palladium(II) complexes with bulky 1-adamantanamine and different halide ligands (chlorine, bromine and iodine). The complexes (1-3) were analytically characterized to confirm their structures by FT-IR, 1H and 13C NMR, HR-MS and XRD techniques for the first time. The interaction of DNA with complexes 1-3 was investigated and the affinity to DNA was confirmed by a DNA binding study, gel electrophoresis and electronic circular dichroism. A protein binding study was carried out and a weak interaction with proteins was found. Finally, the anticancer abilities of palladium complexes 1-3, compared to another cytostatic drug oxaliplatin, were tested and confirmed on the cancer cell lines RAW, HeLa, HOC and HL-60, and the healthy cell line MRC-5.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30502 - Other medical science

Projekt

<a href="/cs/project/GA21-11688S" target="_blank" >GA21-11688S: Core-shell nanočástice pro cílenou fotodynamickou terapii indukovanou RTG zářením</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polyhedron

ISSN

0277-5387

e-ISSN

—

Svazek periodika

209

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

—

Kód UT WoS článku

000697059300005

EID výsledku v databázi Scopus

2-s2.0-85115603345