Cyclotriphosphazene-Based Star Copolymers as Structurally Tunable Nanocarriers with Programmable Biodegradability

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922466" target="_blank" >RIV/60461373:22310/21:43922466 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/21:00541739

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.0c02889#" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.0c02889#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.macromol.0c02889" target="_blank" >10.1021/acs.macromol.0c02889</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cyclotriphosphazene-Based Star Copolymers as Structurally Tunable Nanocarriers with Programmable Biodegradability

Popis výsledku v původním jazyce

Myriad nanocarriers have been developed to improve the therapeutic index of low-molecular-weight drugs for cancer treatment, but many have suboptimal size and/or are too stable for optimal penetration into tumors and their subsequent excretion from the body. To address this challenge, we developed a series of novel nanocarriers based on star polymers consisting of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(ethylene glycol) (PEG) polymer arms attached to hexavalent cyclotriphosphazene (CTP)-derived cores through either stable or stimuli-responsive linkers. The star polymers were assembled using either &quot;grafting from&quot;or &quot;grafting onto&quot;approaches and characterized by quantitative arm substitution at the core. The resulting star polymers were precisely defined water-soluble nanomaterials with a suitable hydrodynamic size (μ10-25 nm) for tumor uptake; those with stimuli-responsive linkers exhibited programmable pH- or cathepsin-mediated degradability. Finally, low-molecular-weight drugs - an anthracycline-based cancerostatic and an imidazoquinoline-based immunostimulant - were linked to exemplary CTP-based star polymers to demonstrate their suitability for drug delivery.

Název v anglickém jazyce

Cyclotriphosphazene-Based Star Copolymers as Structurally Tunable Nanocarriers with Programmable Biodegradability

Popis výsledku anglicky

Myriad nanocarriers have been developed to improve the therapeutic index of low-molecular-weight drugs for cancer treatment, but many have suboptimal size and/or are too stable for optimal penetration into tumors and their subsequent excretion from the body. To address this challenge, we developed a series of novel nanocarriers based on star polymers consisting of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(ethylene glycol) (PEG) polymer arms attached to hexavalent cyclotriphosphazene (CTP)-derived cores through either stable or stimuli-responsive linkers. The star polymers were assembled using either &quot;grafting from&quot;or &quot;grafting onto&quot;approaches and characterized by quantitative arm substitution at the core. The resulting star polymers were precisely defined water-soluble nanomaterials with a suitable hydrodynamic size (μ10-25 nm) for tumor uptake; those with stimuli-responsive linkers exhibited programmable pH- or cathepsin-mediated degradability. Finally, low-molecular-weight drugs - an anthracycline-based cancerostatic and an imidazoquinoline-based immunostimulant - were linked to exemplary CTP-based star polymers to demonstrate their suitability for drug delivery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecules

ISSN

0024-9297

e-ISSN

1520-5835

Svazek periodika

54

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

3139-3157

Kód UT WoS článku

000640891600013

EID výsledku v databázi Scopus

2-s2.0-85104977140