Plasma treatment of PTFE at elevated temperature: The effect of surface properties on its biological performance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43924530" target="_blank" >RIV/60461373:22310/22:43924530 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22320/22:43924530 RIV/44555601:13440/22:43896961

Výsledek na webu

<a href="https://doi.org/10.1016/j.mtcomm.2022.103254" target="_blank" >https://doi.org/10.1016/j.mtcomm.2022.103254</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mtcomm.2022.103254" target="_blank" >10.1016/j.mtcomm.2022.103254</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasma treatment of PTFE at elevated temperature: The effect of surface properties on its biological performance

Popis výsledku v původním jazyce

Polymeric biomaterials play an important role in medicine as catheters, stents, vascular grafts, or artificial heart valves. For example, PTFE has superb thermal stability, low dielectric constant, dissipation factor, excellent chemical inertness and exceptionally low frictional coefficient. However, its applicability is hampered in many cases due to its poor wettability and adhesion to other materials. In our study, we present simple technique of altering surface properties of PTFE by plasma treatment at increased temperature (from 37 °C – body temperature to 121 °C – temperature of sterilization). We have studied the effect of the modification process parameters on surface properties and biological response of the material. For biological tests we have selected vascular smooth muscle cells (VSMC) as a model line for application of our samples for applications where rapid cell growth is undesirable, such as artificial heart valves. The results have shown that proliferation of VSMC on plasma treated PTFE for 480 s at 121 °C is significantly lower compared to standard of tissue culture polystyrene (TCPS). Based on this result the risk of negative response of biological system such as inflammation, immune reactions and coalescence of VSMC in heart valve is minimized. © 2022 Elsevier Ltd

Název v anglickém jazyce

Plasma treatment of PTFE at elevated temperature: The effect of surface properties on its biological performance

Popis výsledku anglicky

Polymeric biomaterials play an important role in medicine as catheters, stents, vascular grafts, or artificial heart valves. For example, PTFE has superb thermal stability, low dielectric constant, dissipation factor, excellent chemical inertness and exceptionally low frictional coefficient. However, its applicability is hampered in many cases due to its poor wettability and adhesion to other materials. In our study, we present simple technique of altering surface properties of PTFE by plasma treatment at increased temperature (from 37 °C – body temperature to 121 °C – temperature of sterilization). We have studied the effect of the modification process parameters on surface properties and biological response of the material. For biological tests we have selected vascular smooth muscle cells (VSMC) as a model line for application of our samples for applications where rapid cell growth is undesirable, such as artificial heart valves. The results have shown that proliferation of VSMC on plasma treated PTFE for 480 s at 121 °C is significantly lower compared to standard of tissue culture polystyrene (TCPS). Based on this result the risk of negative response of biological system such as inflammation, immune reactions and coalescence of VSMC in heart valve is minimized. © 2022 Elsevier Ltd

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Today Communications

ISSN

2352-4928

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

JUN 2022

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

"103254/1"-9

Kód UT WoS článku

000761178900001

EID výsledku v databázi Scopus

2-s2.0-85124376364