Functionalized 2D Germanene and Its Derivatives for Electrochemical Detection of Gut-Derived Metabolites in Human Serum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F23%3A43927568" target="_blank" >RIV/60461373:22310/23:43927568 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2673-4591/48/1/45" target="_blank" >https://www.mdpi.com/2673-4591/48/1/45</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/CSAC2023-14903" target="_blank" >10.3390/CSAC2023-14903</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Functionalized 2D Germanene and Its Derivatives for Electrochemical Detection of Gut-Derived Metabolites in Human Serum

Popis výsledku v původním jazyce

In this work, germanene and its derivatives (Ge-H, Ge-CH3, Ge-C3-CN) were explored as electrochemical impedimetric platforms to develop a competitive immunoassay for the direct detection of gut-derived metabolites, kynurenic acid (KA) and quinolinic acid (QA). The competition occurs between the free KA/QA standards and BSA-conjugated antigens for a fixed amount of primary antibody binding sites. This affects the electron transfer rate of the [Fe(CN)6]3-/4- redox couple and changes the charge transfer resistance (Rct) on the electrode surface. The impedimetric signal measured due to the change in Rct is then correlated to the KA and QA concentration.

Název v anglickém jazyce

Functionalized 2D Germanene and Its Derivatives for Electrochemical Detection of Gut-Derived Metabolites in Human Serum

Popis výsledku anglicky

In this work, germanene and its derivatives (Ge-H, Ge-CH3, Ge-C3-CN) were explored as electrochemical impedimetric platforms to develop a competitive immunoassay for the direct detection of gut-derived metabolites, kynurenic acid (KA) and quinolinic acid (QA). The competition occurs between the free KA/QA standards and BSA-conjugated antigens for a fixed amount of primary antibody binding sites. This affects the electron transfer rate of the [Fe(CN)6]3-/4- redox couple and changes the charge transfer resistance (Rct) on the electrode surface. The impedimetric signal measured due to the change in Rct is then correlated to the KA and QA concentration.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/GX19-26910X" target="_blank" >GX19-26910X: Chemie ve dvou dimenzích - za hranice grafenu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Engineering Proceedings

ISSN

2673-4591

e-ISSN

2673-4591

Svazek periodika

48

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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