The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F24%3A43931421" target="_blank" >RIV/60461373:22310/24:43931421 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/ics.12972" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ics.12972</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ics.12972" target="_blank" >10.1111/ics.12972</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Popis výsledku v původním jazyce

Ceramides are a family of lipids constituted by a sphingoid base and a fatty acid. In the skin, they are mainly present in the stratum corneum where, with cholesterol and free fatty acids, they constitute the inter-corneocyte lipids. With the other lipid groups, they play a key role in the formation of dense lamellar structures between adjacent corneocytes, collectively ensuring the vital efficient barrier to water evaporation and protection from foreign agents´ penetration. Changes in ceramide level and relative composition, with potential impairment of lipid arrangement, have been evidenced in different skin conditions and skin diseases. Therefore, use of suitably formulated ceramides has been proposed for topical treatment to help re-structure damaged lipid arrangement and repair impaired skin barrier function. Nonetheless, the formulation of ceramides in products necessitates specific processes such as heating to high temperature before their introduction in the final formula. In this review on the structure, the role and the potential of ceramides for skincare, we point out the necessity of rigorous process when formulating ceramides into the final product. We demonstrate the counterproductive effects of undissolved ceramides on skin barrier repair capacity of the formulas, when assessed in different in vitro models of disrupted skin barrier. © 2024 Evonik Operations GmbH and The Author(s). International Journal of Cosmetic Science published by John Wiley &amp; Sons Ltd on behalf of Society of Cosmetic Scientists and Societe Francaise de Cosmetologie.

Název v anglickém jazyce

The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Popis výsledku anglicky

Ceramides are a family of lipids constituted by a sphingoid base and a fatty acid. In the skin, they are mainly present in the stratum corneum where, with cholesterol and free fatty acids, they constitute the inter-corneocyte lipids. With the other lipid groups, they play a key role in the formation of dense lamellar structures between adjacent corneocytes, collectively ensuring the vital efficient barrier to water evaporation and protection from foreign agents´ penetration. Changes in ceramide level and relative composition, with potential impairment of lipid arrangement, have been evidenced in different skin conditions and skin diseases. Therefore, use of suitably formulated ceramides has been proposed for topical treatment to help re-structure damaged lipid arrangement and repair impaired skin barrier function. Nonetheless, the formulation of ceramides in products necessitates specific processes such as heating to high temperature before their introduction in the final formula. In this review on the structure, the role and the potential of ceramides for skincare, we point out the necessity of rigorous process when formulating ceramides into the final product. We demonstrate the counterproductive effects of undissolved ceramides on skin barrier repair capacity of the formulas, when assessed in different in vitro models of disrupted skin barrier. © 2024 Evonik Operations GmbH and The Author(s). International Journal of Cosmetic Science published by John Wiley &amp; Sons Ltd on behalf of Society of Cosmetic Scientists and Societe Francaise de Cosmetologie.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

ISSN

0142-5463

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

ZA - Jihoafrická republika

Počet stran výsledku

18

Strana od-do

526-543

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85200668381