Mechanistic insights into dissolution enhancement of co-spray dried meloxicam with chitosan and solubilization agent

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43933328" target="_blank" >RIV/60461373:22310/25:43933328 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-025-31245-1" target="_blank" >https://www.nature.com/articles/s41598-025-31245-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-31245-1" target="_blank" >10.1038/s41598-025-31245-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanistic insights into dissolution enhancement of co-spray dried meloxicam with chitosan and solubilization agent

Popis výsledku v původním jazyce

This study presents a co-spray drying formulation approach to enhance the dissolution rate of meloxicam (MX), a poorly soluble model drug, by combining it with chitosan (CHIT) and sodium lauryl sulfate (SLS). Ternary formulations were prepared using both mini- and medium-scale spray dryers and compared with physical mixtures and RAW MX. In vitro dissolution testing revealed a significant increase in the release rate, with up to 80% of MX dissolved within 5 min. A comprehensive set of solid-state analytical techniques (XRPD, FTIR, and confocal Raman microscopy) revealed subtle changes in MX crystallinity and hydrogen-bonding interactions with both excipients. These findings support three key mechanisms contributing to enhanced dissolution: (i) reduced agglomeration of MX via adsorption onto the CHIT surface, (ii) improved wettability of products due to the presence of SLS, and (iii) increased matrix hydrophilicity facilitating drug-medium contact. The successful scale-up using a medium-scale spray dryer demonstrated the feasibility of this strategy for industrial application. The results highlight co-spray drying with functional excipients as a robust and scalable method for improving the biopharmaceutical performance of poorly soluble drugs. The simple co-spraying of the CHIT dispersion with the drug solution, without the need to dissolve the chitosan, is additional advantage.

Název v anglickém jazyce

Mechanistic insights into dissolution enhancement of co-spray dried meloxicam with chitosan and solubilization agent

Popis výsledku anglicky

This study presents a co-spray drying formulation approach to enhance the dissolution rate of meloxicam (MX), a poorly soluble model drug, by combining it with chitosan (CHIT) and sodium lauryl sulfate (SLS). Ternary formulations were prepared using both mini- and medium-scale spray dryers and compared with physical mixtures and RAW MX. In vitro dissolution testing revealed a significant increase in the release rate, with up to 80% of MX dissolved within 5 min. A comprehensive set of solid-state analytical techniques (XRPD, FTIR, and confocal Raman microscopy) revealed subtle changes in MX crystallinity and hydrogen-bonding interactions with both excipients. These findings support three key mechanisms contributing to enhanced dissolution: (i) reduced agglomeration of MX via adsorption onto the CHIT surface, (ii) improved wettability of products due to the presence of SLS, and (iii) increased matrix hydrophilicity facilitating drug-medium contact. The successful scale-up using a medium-scale spray dryer demonstrated the feasibility of this strategy for industrial application. The results highlight co-spray drying with functional excipients as a robust and scalable method for improving the biopharmaceutical performance of poorly soluble drugs. The simple co-spraying of the CHIT dispersion with the drug solution, without the need to dissolve the chitosan, is additional advantage.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10700 - Other natural sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

nestránkováno

Kód UT WoS článku

001661349500002

EID výsledku v databázi Scopus

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