The role of phosphorylation for regulation of plant PIP2 dependent phospholipase D

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The role of phosphorylation for regulation of plant PIP2 dependent phospholipase D

Popis výsledku v původním jazyce

Membrane phospholipids are due to its position predestinated to mediate signaling on the cell interface and in fact some signaling cascades are triggered by activation of phospholipid cleaving enzymes such as phospholipases C, D and A2 yielding well-known second messengers as DAG, PA, LPA or IP3. Phospholipase D (PLD) liberates from its substrates phophatidic acid (PA) which consequently influences activities of another enzymes [1]. Although PLD was detected first in plants [2] today is much more knownabout biological roles and regulation mechanisms of this enzyme in animals. Partly it is caused by the fact that much more types of PLD exist in plants differing structurally and biochemically [3] than in animals. Phosphorylation of tyrosine is one of theregulation mechanisms described for human PLD1 [4]. We observed concentration dependent inhibitory effect of potato and wheat germ acid phosphatase on the activity of plasma membrane associated PIP2 dependent PLD from Brassica oleracea,

Název v anglickém jazyce

The role of phosphorylation for regulation of plant PIP2 dependent phospholipase D

Popis výsledku anglicky

Membrane phospholipids are due to its position predestinated to mediate signaling on the cell interface and in fact some signaling cascades are triggered by activation of phospholipid cleaving enzymes such as phospholipases C, D and A2 yielding well-known second messengers as DAG, PA, LPA or IP3. Phospholipase D (PLD) liberates from its substrates phophatidic acid (PA) which consequently influences activities of another enzymes [1]. Although PLD was detected first in plants [2] today is much more knownabout biological roles and regulation mechanisms of this enzyme in animals. Partly it is caused by the fact that much more types of PLD exist in plants differing structurally and biochemically [3] than in animals. Phosphorylation of tyrosine is one of theregulation mechanisms described for human PLD1 [4]. We observed concentration dependent inhibitory effect of potato and wheat germ acid phosphatase on the activity of plasma membrane associated PIP2 dependent PLD from Brassica oleracea,

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

FEBS Advanced Course: Lipid signalling and membrane traffic

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

91

Název nakladatele

FEBS Advanced Course on Lipid-mediated signalling in cellula

Místo vydání

Santa Maria Imbaro

Místo konání akce

Santa Maria Imbaro, Itálie

Datum konání akce

20. 6. 2003

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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