Role proteinu CD36 jako vyznamneho rizikoveho faktoru kardiovaskularnich onemocneni

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F06%3A00017207" target="_blank" >RIV/60461373:22330/06:00017207 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

Role proteinu CD36 jako vyznamneho rizikoveho faktoru kardiovaskularnich onemocneni

Popis výsledku v původním jazyce

The human essential hypertension syndrom (syndrom X) including also hyperlipidemia and insulin resistence is a cluster of metabolic disorders whose molecular basis is largely unknown. The most widely studied animal model of hypertension is a Spontaneously Hypertensive Rat (SHR). To identify chromosome region contributing to this clustering of cardiovascular risk factors in the SHR was searched for quantitative trait loci (QTL) associated with insulin resistance, glucose intolerance and dyslipidemia by using recombinant inbred strain. Spontaneously Hypertensive Rat (SHR) displays many of the features of human metabolic disease syndroms thus SHR can be used as a model of mutation in CD36 and study of its protein. Protein CD36 is known as a receptor for thrombospondin-1 and collagen. It also functions as a signal transduction molecule, main glycoprotein of adipocytes and muscle cells, binds long chain fatty acids and functions in their transport through the membrane. CD36 on monocytes and

Název v anglickém jazyce

The role of protein CD36 as an important risc factor of cardiovascular diseases

Popis výsledku anglicky

The human essential hypertension syndrom (syndrom X) including also hyperlipidemia and insulin resistence is a cluster of metabolic disorders whose molecular basis is largely unknown. The most widely studied animal model of hypertension is a Spontaneously Hypertensive Rat (SHR). To identify chromosome region contributing to this clustering of cardiovascular risk factors in the SHR was searched for quantitative trait loci (QTL) associated with insulin resistance, glucose intolerance and dyslipidemia by using recombinant inbred strain. Spontaneously Hypertensive Rat (SHR) displays many of the features of human metabolic disease syndroms thus SHR can be used as a model of mutation in CD36 and study of its protein. Protein CD36 is known as a receptor for thrombospondin-1 and collagen. It also functions as a signal transduction molecule, main glycoprotein of adipocytes and muscle cells, binds long chain fatty acids and functions in their transport through the membrane. CD36 on monocytes and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA301%2F03%2F0751" target="_blank" >GA301/03/0751: Transgenní analýza účinků resistinu na metabolismus uhlovodíků a tuků u spontánně hypertenzních potkanů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

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Číslo periodika v rámci svazku

100

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

17-23

Kód UT WoS článku

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EID výsledku v databázi Scopus

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