Chitosan derivatives as bile acid and cholesterol sorbents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43893068" target="_blank" >RIV/60461373:22330/11:43893068 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chitosan derivatives as bile acid and cholesterol sorbents

Popis výsledku v původním jazyce

This work is devoted to preparation of hydrophobically modified chitosans and evaluation of their sorption properties. N,N,(N)-Di(tri)methylchitosan (MC1) was prepared by the reaction of chitosan with methyl iodide; N,O-palmitoyl-chitosan (MC2) and N,N,(N)-di(tri)methyl-N,O-palmitoyl-chitosan (MC3) were prepared by the reaction of chitosan and MC1 with palmitoyl chloride, respectively. These modified chitosans were characterized by organic elemental analysis, FTIR, NMR, and DSC. The degrees of substitution were calculated from the N/C ratio and from the areas of NMR signals. The in vitro sorption of cholate and cholesterol by chitosan derivatives was studied in comparison with the original chitosan and cholestyramine, an effective synthetic sorbent ofbile acids. It was found that MC2 and MC3 are able to bind cholesterol and bile acids, respectively, and thus can be used as cholestyramine supplements to improve cholesterol metabolism.

Název v anglickém jazyce

Chitosan derivatives as bile acid and cholesterol sorbents

Popis výsledku anglicky

This work is devoted to preparation of hydrophobically modified chitosans and evaluation of their sorption properties. N,N,(N)-Di(tri)methylchitosan (MC1) was prepared by the reaction of chitosan with methyl iodide; N,O-palmitoyl-chitosan (MC2) and N,N,(N)-di(tri)methyl-N,O-palmitoyl-chitosan (MC3) were prepared by the reaction of chitosan and MC1 with palmitoyl chloride, respectively. These modified chitosans were characterized by organic elemental analysis, FTIR, NMR, and DSC. The degrees of substitution were calculated from the N/C ratio and from the areas of NMR signals. The in vitro sorption of cholate and cholesterol by chitosan derivatives was studied in comparison with the original chitosan and cholestyramine, an effective synthetic sorbent ofbile acids. It was found that MC2 and MC3 are able to bind cholesterol and bile acids, respectively, and thus can be used as cholestyramine supplements to improve cholesterol metabolism.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibice intestinální absorpce sterolů hydrofobně modifikovanými polysacharidy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chitin and Chitosan

ISSN

1229-4160

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

KR - Korejská republika

Počet stran výsledku

9

Strana od-do

262-270

Kód UT WoS článku

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EID výsledku v databázi Scopus

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