Antioxidative succinobucol-sterol conjugates: Crystal structures and pseudosymmetry in the crystals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43894012" target="_blank" >RIV/60461373:22330/12:43894012 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/12:00380688

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.molstruc.2011.12.016" target="_blank" >http://dx.doi.org/10.1016/j.molstruc.2011.12.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molstruc.2011.12.016" target="_blank" >10.1016/j.molstruc.2011.12.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antioxidative succinobucol-sterol conjugates: Crystal structures and pseudosymmetry in the crystals

Popis výsledku v původním jazyce

An extensive study to attach succinobucol to sterols has provided conjugates which comprise two pharmaceutically important compounds into one entity where the components are expected to have a synergistic effect. The motivation to design these novel conjugates was the need to broaden the armamentarium of current agents used in the treatment of atherosclerotic diseases and type 2 diabetes. In desire for detailed information of these compounds in solid state, which also have an influence to their physiological activity, systematic crystallization experiments were performed and as a result, X-ray quality single crystals were obtained from four succinobucol-sterol conjugates. All of these compounds crystallized in space group P1 with two or four moleculesin an asymmetric unit and the crystallographically independent molecules were found to be related by pseudosymmetry (i.e. by pseudoinversion in 1-3 and by pseudoinversion plus pseudotranslation in 4).

Název v anglickém jazyce

Antioxidative succinobucol-sterol conjugates: Crystal structures and pseudosymmetry in the crystals

Popis výsledku anglicky

An extensive study to attach succinobucol to sterols has provided conjugates which comprise two pharmaceutically important compounds into one entity where the components are expected to have a synergistic effect. The motivation to design these novel conjugates was the need to broaden the armamentarium of current agents used in the treatment of atherosclerotic diseases and type 2 diabetes. In desire for detailed information of these compounds in solid state, which also have an influence to their physiological activity, systematic crystallization experiments were performed and as a result, X-ray quality single crystals were obtained from four succinobucol-sterol conjugates. All of these compounds crystallized in space group P1 with two or four moleculesin an asymmetric unit and the crystallographically independent molecules were found to be related by pseudosymmetry (i.e. by pseudoinversion in 1-3 and by pseudoinversion plus pseudotranslation in 4).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Structure

ISSN

0022-2860

e-ISSN

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Svazek periodika

1011

Číslo periodika v rámci svazku

03 2012

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

25-33

Kód UT WoS článku

000301316600005

EID výsledku v databázi Scopus

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