Crystallization, Spectral, Crystallographical, and Thermoanalytical Studies of Succinobucol Polymorphism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43894020" target="_blank" >RIV/60461373:22330/12:43894020 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/12:00380695

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jps.23068" target="_blank" >http://dx.doi.org/10.1002/jps.23068</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jps.23068" target="_blank" >10.1002/jps.23068</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Crystallization, Spectral, Crystallographical, and Thermoanalytical Studies of Succinobucol Polymorphism

Popis výsledku v původním jazyce

Four different polymorphs, A, C, D, and E, of succinobucol were isolated and characterized by means of solid-state nuclear magnetic resonance spectroscopy, single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry,and attenuated total reflection-infrared spectroscopy. From a number of experiments, the same polymorphs (C, D, and E) and an equilibrium phase mixture B consisting of polymorphs C and D were repeatedly gained using different solvents or their mixtures.Although polymorph A was obtained directly from recrystallization only on few occasions, polymorphs C, D, and E proved to be metastable kinetic polymorphs, which slowly transform to a thermodynamically more stable form A during long-term storage. The single-crystal structures of polymorph C and D were determined by X-ray single-crystal diffraction.

Název v anglickém jazyce

Crystallization, Spectral, Crystallographical, and Thermoanalytical Studies of Succinobucol Polymorphism

Popis výsledku anglicky

Four different polymorphs, A, C, D, and E, of succinobucol were isolated and characterized by means of solid-state nuclear magnetic resonance spectroscopy, single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry,and attenuated total reflection-infrared spectroscopy. From a number of experiments, the same polymorphs (C, D, and E) and an equilibrium phase mixture B consisting of polymorphs C and D were repeatedly gained using different solvents or their mixtures.Although polymorph A was obtained directly from recrystallization only on few occasions, polymorphs C, D, and E proved to be metastable kinetic polymorphs, which slowly transform to a thermodynamically more stable form A during long-term storage. The single-crystal structures of polymorph C and D were determined by X-ray single-crystal diffraction.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal Pharm.Science

ISSN

0022-3549

e-ISSN

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Svazek periodika

101

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1794-1802

Kód UT WoS článku

000302800100015

EID výsledku v databázi Scopus

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