Analysis of anabolic androgenic steroids by direct analysis in real time ionization with time-of-flight mass spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43899512" target="_blank" >RIV/60461373:22330/15:43899512 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1387380615002730" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1387380615002730</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijms.2015.08.022" target="_blank" >10.1016/j.ijms.2015.08.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of anabolic androgenic steroids by direct analysis in real time ionization with time-of-flight mass spectrometry

Popis výsledku v původním jazyce

We verified applicability of direct analysis in real time ionization coupled with a time-of-flight mass spectrometer (DART-MS) for detection of anabolic androgenic steroids in supplements and pharmaceuticals. DART-MS was optimized for the analysis of eleven frequently misused anabolic androgenic steroids and their derivatives. Real supplement tablets and injectable oil solutions were used to verify applicability of the method. It was found that anabolic androgenic steroids can be analyzed directly without any sample pre-treatment, which reduces the sample preparation time and hence the overall analysis time. The resulting DART-MS method is suitable for rapid routine qualitative screening of anabolic androgenic steroids in simple sample matrices. It has a great potential in the field of adulterated and counterfeited anabolic steroid pharmaceuticals and supplements.

Název v anglickém jazyce

Analysis of anabolic androgenic steroids by direct analysis in real time ionization with time-of-flight mass spectrometry

Popis výsledku anglicky

We verified applicability of direct analysis in real time ionization coupled with a time-of-flight mass spectrometer (DART-MS) for detection of anabolic androgenic steroids in supplements and pharmaceuticals. DART-MS was optimized for the analysis of eleven frequently misused anabolic androgenic steroids and their derivatives. Real supplement tablets and injectable oil solutions were used to verify applicability of the method. It was found that anabolic androgenic steroids can be analyzed directly without any sample pre-treatment, which reduces the sample preparation time and hence the overall analysis time. The resulting DART-MS method is suitable for rapid routine qualitative screening of anabolic androgenic steroids in simple sample matrices. It has a great potential in the field of adulterated and counterfeited anabolic steroid pharmaceuticals and supplements.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/VG20112015045" target="_blank" >VG20112015045: Vývoj rychlých imunochemických testů pro detekci anabolicky aktivních steroidů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Mass Spectrometry

ISSN

1387-3806

e-ISSN

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Svazek periodika

392

Číslo periodika v rámci svazku

DEC 3 2015

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

28-33

Kód UT WoS článku

000366441700005

EID výsledku v databázi Scopus

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