Direct analysis in real time - High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10282186" target="_blank" >RIV/00216208:11160/14:10282186 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/14:43908669
Výsledek na webu
<a href="http://www.sciencedirect.com/science/article/pii/S0039914014005608" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039914014005608</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.talanta.2014.07.007" target="_blank" >10.1016/j.talanta.2014.07.007</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Direct analysis in real time - High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development
Popis výsledku v původním jazyce
In this study, direct analysis in real time-mass spectrometry (DART-MS) was assessed for the analysis of various pharmaceutical formulations with intention to summarize possible applications for the routine pharmaceutical development. As DART is an ambient ionization technique, it allows direct analysis of pharmaceutical samples in solid or liquid form without complex sample preparation, which is often the most time-consuming part of the analytical method. This makes the technique suitable for many application fields, including pharmaceutical drug development. DART mass spectra of more than twenty selected tablets and other common pharmaceutical formulations, i.e. injection solutions, ointments and suppositories developed in the pharmaceutical industryduring several recent years are presented. Moreover, as thin-layer chromatography (TLC) is still very popular for the monitoring of the reactions in the synthetic chemistry, several substances were analyzed directly from the TLC plates t
Název v anglickém jazyce
Direct analysis in real time - High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development
Popis výsledku anglicky
In this study, direct analysis in real time-mass spectrometry (DART-MS) was assessed for the analysis of various pharmaceutical formulations with intention to summarize possible applications for the routine pharmaceutical development. As DART is an ambient ionization technique, it allows direct analysis of pharmaceutical samples in solid or liquid form without complex sample preparation, which is often the most time-consuming part of the analytical method. This makes the technique suitable for many application fields, including pharmaceutical drug development. DART mass spectra of more than twenty selected tablets and other common pharmaceutical formulations, i.e. injection solutions, ointments and suppositories developed in the pharmaceutical industryduring several recent years are presented. Moreover, as thin-layer chromatography (TLC) is still very popular for the monitoring of the reactions in the synthetic chemistry, several substances were analyzed directly from the TLC plates t
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CB - Analytická chemie, separace
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Talanta
ISSN
0039-9140
e-ISSN
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Svazek periodika
130
Číslo periodika v rámci svazku
December
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
9
Strana od-do
518-526
Kód UT WoS článku
000341897800070
EID výsledku v databázi Scopus
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