Tailoring of PEEK bioactivity for improved cell interaction: plasma treatment in action

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43899842" target="_blank" >RIV/60461373:22330/15:43899842 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/15:43899842 RIV/44555601:13440/15:43886689

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c5ra03861h" target="_blank" >http://dx.doi.org/10.1039/c5ra03861h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c5ra03861h" target="_blank" >10.1039/c5ra03861h</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tailoring of PEEK bioactivity for improved cell interaction: plasma treatment in action

Popis výsledku v původním jazyce

Despite the extensive use of polyetheretherketone (PEEK) in biomedical applications, information about cell adhesion on this biomaterial is limited. This study focuses on PEEK tuned by argon plasma treatment with the aim to enhance its wettability and cytocompatibility. Changes in surface properties of the plasma treated surface were studied in relation to the adhesion, proliferation and metabolic activity of mouse fibroblasts (L929) and human osteoblast (U-2 OS) in vitro. Moreover, the expression profiles of two proteins (talin 1 and vinculin) responsible for cell adhesion, were determined at 2 time points in dependence on the PEEK treatment. Plasma treatment increased the surface wettability of PEEK and led to changes in its surface morphology and chemistry. The XPS method showed a decrease in carbon content and augmentation of oxygen concentration with increasing effect of the plasma. Plasma treatment of PEEK significantly enhanced cell adhesion, proliferation and metabolic activity

Název v anglickém jazyce

Tailoring of PEEK bioactivity for improved cell interaction: plasma treatment in action

Popis výsledku anglicky

Despite the extensive use of polyetheretherketone (PEEK) in biomedical applications, information about cell adhesion on this biomaterial is limited. This study focuses on PEEK tuned by argon plasma treatment with the aim to enhance its wettability and cytocompatibility. Changes in surface properties of the plasma treated surface were studied in relation to the adhesion, proliferation and metabolic activity of mouse fibroblasts (L929) and human osteoblast (U-2 OS) in vitro. Moreover, the expression profiles of two proteins (talin 1 and vinculin) responsible for cell adhesion, were determined at 2 time points in dependence on the PEEK treatment. Plasma treatment increased the surface wettability of PEEK and led to changes in its surface morphology and chemistry. The XPS method showed a decrease in carbon content and augmentation of oxygen concentration with increasing effect of the plasma. Plasma treatment of PEEK significantly enhanced cell adhesion, proliferation and metabolic activity

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

52

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

41428-41436

Kód UT WoS článku

000354445900015

EID výsledku v databázi Scopus

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