Ti-alloy with nanotubular surface modification for orthopaedic applications

Kód výsledku v IS VaVaI

RIV/60461373:22330/15:43901139 - isvavai.cz

Nalezeny alternativní kódy

RIV/60461373:22310/15:43901139

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Ti-alloy with nanotubular surface modification for orthopaedic applications

Popis výsledku v původním jazyce

Titanium and its alloys have been widely used for permanent orthopaedic implants; however, they are considered as bioinert, which means that fibrous layer is often formed on the implant-bone interface. For better integration of the implant that could accelerate healing and prolong lifespan of the implant, material surfaces can be modified in various ways. It has been shown that nanotopography influences cell adhesion and differentiation1. Anodic oxidation in appropriate electrolytes2 is a method which can be used for scale-up nanopatterning of metallic materials. Specific parameters of the nanotubes and their influence on the cell growth have been extensively studied recently. Interestingly, various authors obtained contradictory results when performing in vitro tests with TiO2 nanotubes (diameter 15 - 100 nm) using mesenchymal stem cells (MSCs) 3, 4. Our aim was to perform in vitro tests with nanotubular surfaces on commercial titanium alloy and to study the influence of the nanostruc

Název v anglickém jazyce

Ti-alloy with nanotubular surface modification for orthopaedic applications

Popis výsledku anglicky

Titanium and its alloys have been widely used for permanent orthopaedic implants; however, they are considered as bioinert, which means that fibrous layer is often formed on the implant-bone interface. For better integration of the implant that could accelerate healing and prolong lifespan of the implant, material surfaces can be modified in various ways. It has been shown that nanotopography influences cell adhesion and differentiation1. Anodic oxidation in appropriate electrolytes2 is a method which can be used for scale-up nanopatterning of metallic materials. Specific parameters of the nanotubes and their influence on the cell growth have been extensively studied recently. Interestingly, various authors obtained contradictory results when performing in vitro tests with TiO2 nanotubes (diameter 15 - 100 nm) using mesenchymal stem cells (MSCs) 3, 4. Our aim was to perform in vitro tests with nanotubular surfaces on commercial titanium alloy and to study the influence of the nanostruc

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

TE01020390: Centrum vývoje moderních kovových biomateriálů pro lékařské implantáty

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů