Using nutritional and oxidative stress to increase content of health-beneficial fatty acids in oleaginous and non-oleaginous yeasts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43901627" target="_blank" >RIV/60461373:22330/16:43901627 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1515/chempap-2016-0060" target="_blank" >http://dx.doi.org/10.1515/chempap-2016-0060</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/chempap-2016-0060" target="_blank" >10.1515/chempap-2016-0060</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Using nutritional and oxidative stress to increase content of health-beneficial fatty acids in oleaginous and non-oleaginous yeasts

Popis výsledku v původním jazyce

Yeast responses to stress conditions include an increase in lipid content and concomitant changes in content of saturated and unsaturated fatty acids. Some fatty acids are among the dietetically important fatty acids and new possibilities are sought for their biotechnological production in addition to those already exploited from marine organisms, nuts and other sources. The possibility of the production of palmitoleic and linoleic acids resulting from new approaches to traditional biotechnologically useful yeast species (Kluyveromyces polysporus, Saccharomyces cerevisiae, Torulospora delbrueckii) and species capable of high accumulation of lipids (Rhodotorula glutinis, Trichosporon cutaneum, Candida sp., Yarrowia lipolytica) was explored. The most promising was the combination of two stress factors: limitation of N-sources (C/N mass ratio of 70 : 1) and oxidative stress induced by zero-valent iron nanoparticles. These conditions were conducive to the production of palmitoleic acid commonly used in cosmetics and medicine and omega-6-linoleic acid, a precursor of thromboxanes, prostaglandins and leucotrienes. The yield of these two fatty acids in T. cutaneum was more than 500 mg g(-1) (dry mass) and in Candida sp. more than 600 mg g(-1) (dry mass).

Název v anglickém jazyce

Using nutritional and oxidative stress to increase content of health-beneficial fatty acids in oleaginous and non-oleaginous yeasts

Popis výsledku anglicky

Yeast responses to stress conditions include an increase in lipid content and concomitant changes in content of saturated and unsaturated fatty acids. Some fatty acids are among the dietetically important fatty acids and new possibilities are sought for their biotechnological production in addition to those already exploited from marine organisms, nuts and other sources. The possibility of the production of palmitoleic and linoleic acids resulting from new approaches to traditional biotechnologically useful yeast species (Kluyveromyces polysporus, Saccharomyces cerevisiae, Torulospora delbrueckii) and species capable of high accumulation of lipids (Rhodotorula glutinis, Trichosporon cutaneum, Candida sp., Yarrowia lipolytica) was explored. The most promising was the combination of two stress factors: limitation of N-sources (C/N mass ratio of 70 : 1) and oxidative stress induced by zero-valent iron nanoparticles. These conditions were conducive to the production of palmitoleic acid commonly used in cosmetics and medicine and omega-6-linoleic acid, a precursor of thromboxanes, prostaglandins and leucotrienes. The yield of these two fatty acids in T. cutaneum was more than 500 mg g(-1) (dry mass) and in Candida sp. more than 600 mg g(-1) (dry mass).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

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Projekt

<a href="/cs/project/GA14-00227S" target="_blank" >GA14-00227S: Mikroorganizmy jako zdroje esenciálních mastných kyselin se zaměřením na extremofilní kmeny</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

0366-6352

e-ISSN

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Svazek periodika

70

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

9

Strana od-do

1351-1359

Kód UT WoS článku

000379758000005

EID výsledku v databázi Scopus

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