Bioresource of Antioxidant and Potential Medicinal Compounds from Waste Biomass of Spruce

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F17%3A43914847" target="_blank" >RIV/60461373:22330/17:43914847 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22810/17:43914847

Výsledek na webu

<a href="https://pubs.acs.org/doi/pdf/10.1021/acssuschemeng.7b01816" target="_blank" >https://pubs.acs.org/doi/pdf/10.1021/acssuschemeng.7b01816</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acssuschemeng.7b01816" target="_blank" >10.1021/acssuschemeng.7b01816</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bioresource of Antioxidant and Potential Medicinal Compounds from Waste Biomass of Spruce

Popis výsledku v původním jazyce

The bark of Norway spruce (Picea abies) has been a source of medications for centuries. Despite that, bark is a waste biomass produced by wood industry in million tons annually. The most abundant compounds obtained from hexane extracts of bark were sterols and terpenes subjected to in silico analysis. Their absorption, distribution, metabolism and excretion properties and possible types of biological activities were predicted. Abietic acid, dehydroabietic acid and β-caryophyllene oxide originated from bark of Norway spruce had most likely antihypercholesterolemic, mucomembranous protecting and antineoplastic activity, respectively. An important discovery was estimation of their pharmaceutically relevant properties. Isolated fractions that were rich in these compounds (contained them up to 30%) displayed excellent trolox equivalent antioxidant capacity (15 mM/mg dm), which was 2.5 times greater than the source of powerful antioxidant, pycnogenol. Antioxidant activity of extracts and fractions determined using a DPPH assay were moreover investigated by EPR analysis of prolongation ascorbyl radical lifetime and rapid oxidation in lard. We found out that bark is an alternative feedstock of compounds with a potential antioxidant and medicinal activity that may replace synthetic drugs. Healing effect, antioxidant capacity, prolongation of ascorbyl radical lifetime and stabilization of lipids with compounds of spruce bark have not yet been published.

Název v anglickém jazyce

Bioresource of Antioxidant and Potential Medicinal Compounds from Waste Biomass of Spruce

Popis výsledku anglicky

The bark of Norway spruce (Picea abies) has been a source of medications for centuries. Despite that, bark is a waste biomass produced by wood industry in million tons annually. The most abundant compounds obtained from hexane extracts of bark were sterols and terpenes subjected to in silico analysis. Their absorption, distribution, metabolism and excretion properties and possible types of biological activities were predicted. Abietic acid, dehydroabietic acid and β-caryophyllene oxide originated from bark of Norway spruce had most likely antihypercholesterolemic, mucomembranous protecting and antineoplastic activity, respectively. An important discovery was estimation of their pharmaceutically relevant properties. Isolated fractions that were rich in these compounds (contained them up to 30%) displayed excellent trolox equivalent antioxidant capacity (15 mM/mg dm), which was 2.5 times greater than the source of powerful antioxidant, pycnogenol. Antioxidant activity of extracts and fractions determined using a DPPH assay were moreover investigated by EPR analysis of prolongation ascorbyl radical lifetime and rapid oxidation in lard. We found out that bark is an alternative feedstock of compounds with a potential antioxidant and medicinal activity that may replace synthetic drugs. Healing effect, antioxidant capacity, prolongation of ascorbyl radical lifetime and stabilization of lipids with compounds of spruce bark have not yet been published.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21100 - Other engineering and technologies

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Sustainable Chemistry &amp; Engineering

ISSN

2168-0485

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

"8161 "- 8170

Kód UT WoS článku

000410006200079

EID výsledku v databázi Scopus

2-s2.0-85028937963