Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F19%3A43917984" target="_blank" >RIV/60461373:22330/19:43917984 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/18:76778 RIV/60460709:41340/18:76778 RIV/60460709:41340/19:79954 RIV/60460709:41210/19:79954

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1462180" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1462180</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14786419.2018.1462180" target="_blank" >10.1080/14786419.2018.1462180</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential

Popis výsledku v původním jazyce

Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 mu g TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.

Název v anglickém jazyce

Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential

Popis výsledku anglicky

Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 mu g TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40401 - Agricultural biotechnology and food biotechnology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Natural Product Research

ISSN

1478-6419

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

18

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

2718-2721

Kód UT WoS článku

000475501100021

EID výsledku v databázi Scopus

2-s2.0-85045441418