Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A76778" target="_blank" >RIV/60460709:41210/18:76778 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60460709:41340/18:76778 RIV/60460709:41340/19:79954 RIV/60460709:41210/19:79954 RIV/60461373:22330/19:43917984
Výsledek na webu
<a href="http://dx.doi.org/10.1080/14786419.2018.1462180" target="_blank" >http://dx.doi.org/10.1080/14786419.2018.1462180</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14786419.2018.1462180" target="_blank" >10.1080/14786419.2018.1462180</a>
Alternativní jazyky
Jazyk výsledku
čeština
Název v původním jazyce
Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
Popis výsledku v původním jazyce
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and antiproliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80,6 and 687,3 ug TE/mg extract, respectively. IC50 against Caco-2, HT-29 and Hep-G2 = 129,2, 69,9 and 130,6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or antiproliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/antiproliferative activity of this plant should be ca
Název v anglickém jazyce
Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
Popis výsledku anglicky
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and antiproliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80,6 and 687,3 ug TE/mg extract, respectively. IC50 against Caco-2, HT-29 and Hep-G2 = 129,2, 69,9 and 130,6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or antiproliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/antiproliferative activity of this plant should be ca
Klasifikace
Druh
J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
NATURAL PRODUCT RESEARCH
ISSN
1478-6419
e-ISSN
1478-6427
Svazek periodika
N
Číslo periodika v rámci svazku
14 Apr 2018
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
4
Strana od-do
1-4
Kód UT WoS článku
—
EID výsledku v databázi Scopus
2-s2.0-85045441418