Design of Mechanically Stirred Bioreactors and Exploitation of Control Software for Aerobic Cultivation of Microbial Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F19%3A43918662" target="_blank" >RIV/60461373:22330/19:43918662 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Design of Mechanically Stirred Bioreactors and Exploitation of Control Software for Aerobic Cultivation of Microbial Cells

Popis výsledku v původním jazyce

Control functions of the INFORS HT bioreactor Labfors 5 are described and discussed concerning their application for aerobic cultivation of dense cultures of microbial cells. A practical example was demonstrated cultivation of Pichia pastoris, facultative methylotrophic yeast producing under specific conditions recombinant proteins. A strategy of feeding the repressive and inducing substrates was tested aiming at the optimal process parameters. A similar example of computer-controlled cultivation is that of the yeast culture of Saccharomyces cerevisiae. The cultivation is performed in a fed-batch system and under special conditions can lead to an increased content of intracellular sterol - ergosterol (provitamin D2).

Název v anglickém jazyce

Design of Mechanically Stirred Bioreactors and Exploitation of Control Software for Aerobic Cultivation of Microbial Cells

Popis výsledku anglicky

Control functions of the INFORS HT bioreactor Labfors 5 are described and discussed concerning their application for aerobic cultivation of dense cultures of microbial cells. A practical example was demonstrated cultivation of Pichia pastoris, facultative methylotrophic yeast producing under specific conditions recombinant proteins. A strategy of feeding the repressive and inducing substrates was tested aiming at the optimal process parameters. A similar example of computer-controlled cultivation is that of the yeast culture of Saccharomyces cerevisiae. The cultivation is performed in a fed-batch system and under special conditions can lead to an increased content of intracellular sterol - ergosterol (provitamin D2).

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Measurement and Control of Chemical, Food and Biotechnological Processes, Volume II: Process Control

ISBN

978-1-908235-10-7

Počet stran výsledku

11

Strana od-do

282-292

Počet stran knihy

656

Název nakladatele

STS Science Centre Ltd.

Místo vydání

London

Kód UT WoS kapitoly

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