Lipidomic analysis to assess oxidative stress in acute coronary syndrome and acute stroke patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922710" target="_blank" >RIV/60461373:22330/21:43922710 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023736:_____/21:00013255 RIV/61383082:_____/21:00001052 RIV/00216208:11110/21:10429674

Výsledek na webu

<a href="https://www.mdpi.com/2218-1989/11/7/412" target="_blank" >https://www.mdpi.com/2218-1989/11/7/412</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/metabo11070412" target="_blank" >10.3390/metabo11070412</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lipidomic analysis to assess oxidative stress in acute coronary syndrome and acute stroke patients

Popis výsledku v původním jazyce

Alterations in lipid metabolism mediated by oxidative stress play a key role in the process of atherosclerosis and superimposed thrombosis; these can lead to acute coronary syndrome (ACS) and acute ischemic stroke (AIS). Multiple studies have shown that the formation of atheromatous lesions is initiated by oxidation of low-density lipoproteins incorporated into the intima of the vessel wall. Here, we studied lipids in plasma samples from three cohorts: 61 patients with ACS (group A), 49 patients with AIS (group D), and 82 controls (group K). Untargeted lipidomics based on high-performance liquid chromatography coupled to mass spectrometry (UHPLC-HRMS) was employed to obtain comprehensive information on whether relationships exist between these patient categories based on lipid patterns. In addition, malondialdehyde (MDA) as a standard marker of oxidative stress was monitored. The most characteristic lipids in group K were fatty acyls of hydroxyfatty acids (FAHFAs). As expected, MDA concentrations were the lowest in group K. Our findings can better explain ongoing pathologies, both acute and chronic, with the potential for future diagnosis and treatment. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Název v anglickém jazyce

Lipidomic analysis to assess oxidative stress in acute coronary syndrome and acute stroke patients

Popis výsledku anglicky

Alterations in lipid metabolism mediated by oxidative stress play a key role in the process of atherosclerosis and superimposed thrombosis; these can lead to acute coronary syndrome (ACS) and acute ischemic stroke (AIS). Multiple studies have shown that the formation of atheromatous lesions is initiated by oxidation of low-density lipoproteins incorporated into the intima of the vessel wall. Here, we studied lipids in plasma samples from three cohorts: 61 patients with ACS (group A), 49 patients with AIS (group D), and 82 controls (group K). Untargeted lipidomics based on high-performance liquid chromatography coupled to mass spectrometry (UHPLC-HRMS) was employed to obtain comprehensive information on whether relationships exist between these patient categories based on lipid patterns. In addition, malondialdehyde (MDA) as a standard marker of oxidative stress was monitored. The most characteristic lipids in group K were fatty acyls of hydroxyfatty acids (FAHFAs). As expected, MDA concentrations were the lowest in group K. Our findings can better explain ongoing pathologies, both acute and chronic, with the potential for future diagnosis and treatment. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV18-08-00149" target="_blank" >NV18-08-00149: Kritické zhodnocení lipidomu u pacientů s akutním koronárním syndromem a cévní mozkovou příhodou ve vztahu ke stupni oxidačního stresu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Metabolites

ISSN

2218-1989

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

—

Kód UT WoS článku

000676224200001

EID výsledku v databázi Scopus

2-s2.0-85109191097