Antimicrobial and antivirulence activity of pterostilbene, methoxylated derivative of resveratrol
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43925611" target="_blank" >RIV/60461373:22330/21:43925611 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf" target="_blank" >https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf</a>
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antimicrobial and antivirulence activity of pterostilbene, methoxylated derivative of resveratrol
Popis výsledku v původním jazyce
With and increased incidence of antibiotic resistance among pathogenic bacteria and fungi, there is a great pressure on novel drug development. The research is now focused on drugs with potential antivirulence activity rather than traditional antimicrobial substances due to decreased selective pressure on treated pathogen and lower probability of resistance development. The presented study observed antimicrobial and antibiofilm effect of natural compound pterostilbene compared to traditional macrolide antibiotic – erythromycin on clinically relevant staphylococci.Pterostilbene was effective against both suspension growth and biofilm formation in contrast to erythromycin. Pterostilbene was found to have bactericidal action on Staphylococcus aureus and in combination (49 mg/l) with antibiotic it enhanced erythromycin (5 mg/l) activity and decreased biofilm formation by more than 80% in all studied strains of Staphylococcus epidermidis. Studied stilbene was proved to be a suitable complement of otherwise ineffective antibiotics in treatment of infectious diseases caused by representatives of genus Staphylococcus.
Název v anglickém jazyce
Antimicrobial and antivirulence activity of pterostilbene, methoxylated derivative of resveratrol
Popis výsledku anglicky
With and increased incidence of antibiotic resistance among pathogenic bacteria and fungi, there is a great pressure on novel drug development. The research is now focused on drugs with potential antivirulence activity rather than traditional antimicrobial substances due to decreased selective pressure on treated pathogen and lower probability of resistance development. The presented study observed antimicrobial and antibiofilm effect of natural compound pterostilbene compared to traditional macrolide antibiotic – erythromycin on clinically relevant staphylococci.Pterostilbene was effective against both suspension growth and biofilm formation in contrast to erythromycin. Pterostilbene was found to have bactericidal action on Staphylococcus aureus and in combination (49 mg/l) with antibiotic it enhanced erythromycin (5 mg/l) activity and decreased biofilm formation by more than 80% in all studied strains of Staphylococcus epidermidis. Studied stilbene was proved to be a suitable complement of otherwise ineffective antibiotics in treatment of infectious diseases caused by representatives of genus Staphylococcus.
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
—
OECD FORD obor
10606 - Microbiology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
Proceedings of the 8th International Conference on Chemical Technology
ISBN
978-80-88307-08-2
ISSN
—
e-ISSN
—
Počet stran výsledku
4
Strana od-do
277-280
Název nakladatele
Czech Society of Industrial Chemistry
Místo vydání
Prague
Místo konání akce
Praha
Datum konání akce
3. 5. 2021
Typ akce podle státní příslušnosti
WRD - Celosvětová akce
Kód UT WoS článku
—