Synthesis of phosphonate derivatives of 2 '-deoxy-2 '-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43933937" target="_blank" >RIV/60461373:22330/21:43933937 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/21:00543389

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0040402021003458?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0040402021003458?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tet.2021.132159" target="_blank" >10.1016/j.tet.2021.132159</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of phosphonate derivatives of 2 '-deoxy-2 '-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides

Popis výsledku v původním jazyce

Analogs of nucleosides and nucleotides represent a promising pool of potential therapeutics. This work describes a new synthetic route leading to 2 &apos;-deoxy-2 &apos;-fluorotetradialdose D-nucleoside phosphonates. Moreover, a new universal synthetic route leading to tetradialdose D-nucleosides bearing purine nucleobases is also described. All new compounds were tested as triphosphate analogs for inhibitory potency against a variety of viral polymerases. The fluorinated nucleosides were transformed to phosphoramidate prodrugs and evaluated in cell cultures against various viruses including influenza and SARS-CoV-2. (C) 2021 Elsevier Ltd. All rights reserved.

Název v anglickém jazyce

Synthesis of phosphonate derivatives of 2 '-deoxy-2 '-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides

Popis výsledku anglicky

Analogs of nucleosides and nucleotides represent a promising pool of potential therapeutics. This work describes a new synthetic route leading to 2 &apos;-deoxy-2 &apos;-fluorotetradialdose D-nucleoside phosphonates. Moreover, a new universal synthetic route leading to tetradialdose D-nucleosides bearing purine nucleobases is also described. All new compounds were tested as triphosphate analogs for inhibitory potency against a variety of viral polymerases. The fluorinated nucleosides were transformed to phosphoramidate prodrugs and evaluated in cell cultures against various viruses including influenza and SARS-CoV-2. (C) 2021 Elsevier Ltd. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

TETRAHEDRON

ISSN

0040-4020

e-ISSN

1464-5416

Svazek periodika

89

Číslo periodika v rámci svazku

4. června 2021

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

18

Strana od-do

nestránkováno

Kód UT WoS článku

000659206000014

EID výsledku v databázi Scopus

2-s2.0-85104947933