Evaluation of the Body Burden of Short- and Medium-Chain Chlorinated Paraffins in the Blood Serum of Residents of the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F24%3A43930621" target="_blank" >RIV/60461373:22330/24:43930621 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2039-4713/14/4/107" target="_blank" >https://www.mdpi.com/2039-4713/14/4/107</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jox14040107" target="_blank" >10.3390/jox14040107</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of the Body Burden of Short- and Medium-Chain Chlorinated Paraffins in the Blood Serum of Residents of the Czech Republic

Popis výsledku v původním jazyce

Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) are environmental contaminants known for their persistence and bioaccumulation in fatty tissues. SCCPs are considered potential carcinogens and endocrine disruptors, with similar effects expected for MCCPs. This study investigated the body burden of SCCPs and MCCPs in residents of two regions of the Czech Republic with different levels of industrial pollution. Blood serum samples from 62 individuals in Ceske Budejovice (control area) and Ostrava (industrial area) were analysed. The results showed higher concentrations of SCCPs (&lt;120–650 ng/g lipid weight (lw)) and MCCPs (&lt;240–1530 ng/g lw) in Ostrava compared to Ceske Budejovice (SCCPs: &lt;120–210 ng/g lw, MCCPs: &lt;240–340 ng/g lw). The statistical analysis revealed no significant correlations between chemical concentrations and demographic variables such as age, BMI, or gender. The findings are consistent with European and Australian studies but significantly lower than levels reported in China. This is the first comprehensive survey of SCCPs and MCCPs in human blood serum in the Czech Republic and the second study in Europe. The data collected in this study are essential for assessing SCCPs and MCCPs. They will contribute to a better understanding the potential health risks associated with exposure to these chemicals. © 2024 by the authors.

Název v anglickém jazyce

Evaluation of the Body Burden of Short- and Medium-Chain Chlorinated Paraffins in the Blood Serum of Residents of the Czech Republic

Popis výsledku anglicky

Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) are environmental contaminants known for their persistence and bioaccumulation in fatty tissues. SCCPs are considered potential carcinogens and endocrine disruptors, with similar effects expected for MCCPs. This study investigated the body burden of SCCPs and MCCPs in residents of two regions of the Czech Republic with different levels of industrial pollution. Blood serum samples from 62 individuals in Ceske Budejovice (control area) and Ostrava (industrial area) were analysed. The results showed higher concentrations of SCCPs (&lt;120–650 ng/g lipid weight (lw)) and MCCPs (&lt;240–1530 ng/g lw) in Ostrava compared to Ceske Budejovice (SCCPs: &lt;120–210 ng/g lw, MCCPs: &lt;240–340 ng/g lw). The statistical analysis revealed no significant correlations between chemical concentrations and demographic variables such as age, BMI, or gender. The findings are consistent with European and Australian studies but significantly lower than levels reported in China. This is the first comprehensive survey of SCCPs and MCCPs in human blood serum in the Czech Republic and the second study in Europe. The data collected in this study are essential for assessing SCCPs and MCCPs. They will contribute to a better understanding the potential health risks associated with exposure to these chemicals. © 2024 by the authors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/GA21-19437S" target="_blank" >GA21-19437S: Vliv nových chlorovaných kontaminantů na adipogenezi</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Xenobiotics

ISSN

2039-4705

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

LT - Litevská republika

Počet stran výsledku

12

Strana od-do

2003-2014

Kód UT WoS článku

001387495700001

EID výsledku v databázi Scopus

2-s2.0-85213453272