Short- and medium-chain chlorinated paraffins in human blood serum of Czech population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922794" target="_blank" >RIV/60461373:22330/21:43922794 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/21:00552852

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0048969721041991?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0048969721041991?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.scitotenv.2021.149126" target="_blank" >10.1016/j.scitotenv.2021.149126</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Short- and medium-chain chlorinated paraffins in human blood serum of Czech population

Popis výsledku v původním jazyce

Short- and medium-chain chlorinated paraffins (SCCPs; MCCPs) are widespread environmental pollutants with bioaccumulation potential and adverse effects on human health. The analysis of blood serum is an important strategy to assess the human exposure to various contaminants, including SCCPs and MCCPs. Lately, the information about the exposure of Chinese population has been reported; nevertheless, data on human exposure to SCCPs and MCCPs outside East Asia are still very limited. In this pilot study, SCCPs and MCCPs were determined in 27 serum samples obtained from Czech adults. The samples were extracted by a three-step extraction (repeated with a clean solvent) by a mixture of n-hexane:diethyl ether (9:1, v/v) with subsequent clean-up on Florisil® solid phase extraction column. Gas chromatography coupled with high resolution mass spectrometry operated in negative chemical ionisation was employed for the instrumental analysis. The method recoveries ranged from 71 to 89% with repeatabilities of &lt;20% (expressed as relative standard deviation). In the samples, SCCP concentrations were in the range of &lt;150–2600 ng/g lipid weight, lw (median 370 ng/g lw) and the MCCP concentrations were in the range of &lt;200–2110 ng/g lw (median 360 ng/g lw), respectively. To the best of our knowledge, our reported results are the first data about chlorinated paraffins in human blood serum in Europe, showing exposure to these compounds with yet to be studied effects on human health. © 2021 Elsevier B.V.

Název v anglickém jazyce

Short- and medium-chain chlorinated paraffins in human blood serum of Czech population

Popis výsledku anglicky

Short- and medium-chain chlorinated paraffins (SCCPs; MCCPs) are widespread environmental pollutants with bioaccumulation potential and adverse effects on human health. The analysis of blood serum is an important strategy to assess the human exposure to various contaminants, including SCCPs and MCCPs. Lately, the information about the exposure of Chinese population has been reported; nevertheless, data on human exposure to SCCPs and MCCPs outside East Asia are still very limited. In this pilot study, SCCPs and MCCPs were determined in 27 serum samples obtained from Czech adults. The samples were extracted by a three-step extraction (repeated with a clean solvent) by a mixture of n-hexane:diethyl ether (9:1, v/v) with subsequent clean-up on Florisil® solid phase extraction column. Gas chromatography coupled with high resolution mass spectrometry operated in negative chemical ionisation was employed for the instrumental analysis. The method recoveries ranged from 71 to 89% with repeatabilities of &lt;20% (expressed as relative standard deviation). In the samples, SCCP concentrations were in the range of &lt;150–2600 ng/g lipid weight, lw (median 370 ng/g lw) and the MCCP concentrations were in the range of &lt;200–2110 ng/g lw (median 360 ng/g lw), respectively. To the best of our knowledge, our reported results are the first data about chlorinated paraffins in human blood serum in Europe, showing exposure to these compounds with yet to be studied effects on human health. © 2021 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science of the Total Environment

ISSN

0048-9697

e-ISSN

—

Svazek periodika

797

Číslo periodika v rámci svazku

149126

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

000704363800006

EID výsledku v databázi Scopus

2-s2.0-85110716032