Are fish oil-based dietary supplements a significant source of exposure to chlorinated paraffins?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925099" target="_blank" >RIV/60461373:22330/22:43925099 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.scitotenv.2022.155137" target="_blank" >https://doi.org/10.1016/j.scitotenv.2022.155137</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.scitotenv.2022.155137" target="_blank" >10.1016/j.scitotenv.2022.155137</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Are fish oil-based dietary supplements a significant source of exposure to chlorinated paraffins?

Popis výsledku v původním jazyce

Chlorinated paraffins (CPs) are an emerging group of environmental pollutants associated with adverse effects on human health (such as endocrine disruption and possible carcinogenicity). CPs are classified into several groups: short- (SCCPs), medium- (MCCPs) and long-chain chlorinated paraffins (LCCPs). In this study, CPs were determined in fish oil-based omega-3 dietary supplements (DS) representing widely consumed products that might be contaminated with various lipophilic contaminants including CPs. The CPs were isolated from DS (n = 85) by solid phase extraction. The SCCPs and MCCPs were determined by gas chromatography coupled with high-resolution mass spectrometry operated in a negative chemical ionisation mode. The LCCPs (up to C21) were screened using supercritical fluid chromatography coupled with high-resolution mass spectrometry with electrospray ionisation operated in negative mode. The CP concentrations varied from &lt;0.01 to 56.48 μg/g fat for SCCPs (median 0.12 μg/g fat; limit of quantification, LOQ, for SCCPs was exceeded in 51 out of 85 samples) and from &lt;0.03–89.08 μg/g fat for MCCPs (median 0.26 μg/g fat; LOQ for MCCPs was exceeded in 66 out of 85 samples), respectively. The LCCPs were not quantified in this study, nevertheless their limit of detection (0.5 μg/g fat) was exceeded in 7 out of 85 samples. Due to high levels of CPs, DS might pose as a significant source of CPs exposure to some population groups. © 2022 Elsevier B.V.

Název v anglickém jazyce

Are fish oil-based dietary supplements a significant source of exposure to chlorinated paraffins?

Popis výsledku anglicky

Chlorinated paraffins (CPs) are an emerging group of environmental pollutants associated with adverse effects on human health (such as endocrine disruption and possible carcinogenicity). CPs are classified into several groups: short- (SCCPs), medium- (MCCPs) and long-chain chlorinated paraffins (LCCPs). In this study, CPs were determined in fish oil-based omega-3 dietary supplements (DS) representing widely consumed products that might be contaminated with various lipophilic contaminants including CPs. The CPs were isolated from DS (n = 85) by solid phase extraction. The SCCPs and MCCPs were determined by gas chromatography coupled with high-resolution mass spectrometry operated in a negative chemical ionisation mode. The LCCPs (up to C21) were screened using supercritical fluid chromatography coupled with high-resolution mass spectrometry with electrospray ionisation operated in negative mode. The CP concentrations varied from &lt;0.01 to 56.48 μg/g fat for SCCPs (median 0.12 μg/g fat; limit of quantification, LOQ, for SCCPs was exceeded in 51 out of 85 samples) and from &lt;0.03–89.08 μg/g fat for MCCPs (median 0.26 μg/g fat; LOQ for MCCPs was exceeded in 66 out of 85 samples), respectively. The LCCPs were not quantified in this study, nevertheless their limit of detection (0.5 μg/g fat) was exceeded in 7 out of 85 samples. Due to high levels of CPs, DS might pose as a significant source of CPs exposure to some population groups. © 2022 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

<a href="/cs/project/GA21-19437S" target="_blank" >GA21-19437S: Vliv nových chlorovaných kontaminantů na adipogenezi</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science of the Total Environment

ISSN

0048-9697

e-ISSN

1879-1026

Svazek periodika

833

Číslo periodika v rámci svazku

AUG 10 2022

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

nestrankovano

Kód UT WoS článku

000808120000011

EID výsledku v databázi Scopus

2-s2.0-85128576360