Challenges of cannabidiol determination in emulsified cosmetics and application of solid‑phase extraction followed by HPLC‑UV‑MS/MS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F25%3A43930219" target="_blank" >RIV/60461373:22330/25:43930219 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/25:43930219

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00216-024-05716-9" target="_blank" >https://link.springer.com/article/10.1007/s00216-024-05716-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00216-024-05716-9" target="_blank" >10.1007/s00216-024-05716-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Challenges of cannabidiol determination in emulsified cosmetics and application of solid‑phase extraction followed by HPLC‑UV‑MS/MS

Popis výsledku v původním jazyce

The recent surge in popularity of cannabidiol-infused products extends beyond food and supplements to the cosmetic industry. Accurate labeling remains a significant concern, as many products fail to meet advertised cannabidiol content and/or contain psychoactive tetrahydrocannabinol above the permissible levels. In this work, we present the use of an HPLC-UV-MS/MS method for the quantification of five major cannabinoids (cannabidiol, cannabidiolic acid, tetrahydrocannabinol, tetrahydrocannabinolic acid, and cannabigerol) in oil-in-water cosmetic emulsions. The sample extraction is based on dispersing the sample in isopropanol, followed by solid-phase extraction using Bond Elut Plexa PAX cartridge. The viability of this method is demonstrated by comparing matrix effects in samples subjected to solid-phase extraction (0‒11% suppression of cannabidiol ionization) to samples extracted without additional purification steps (0‒84% ionization suppression of cannabidiol ionization). The limit of quantification is determined at 0.1 mg/g and the calibration is employed in the range of 0.1‒50 mg/g for cannabidiol and 0.1‒10 mg/g for all other analytes. Finally, 36 real cosmetic samples from the Czech market were analyzed. Of these, 14 indicated the amount of CBD on the label but only five (36%) were accurate, i.e., within 90‒110% of the labeled amount, and a considerable amount of THC (0.16 ± 0.01 mg/g) was found in one sample. These findings contribute to the cumulating evidence that cannabidiol-based consumer products are often mislabeled and highlight the importance of better regulatory compliance.

Název v anglickém jazyce

Challenges of cannabidiol determination in emulsified cosmetics and application of solid‑phase extraction followed by HPLC‑UV‑MS/MS

Popis výsledku anglicky

The recent surge in popularity of cannabidiol-infused products extends beyond food and supplements to the cosmetic industry. Accurate labeling remains a significant concern, as many products fail to meet advertised cannabidiol content and/or contain psychoactive tetrahydrocannabinol above the permissible levels. In this work, we present the use of an HPLC-UV-MS/MS method for the quantification of five major cannabinoids (cannabidiol, cannabidiolic acid, tetrahydrocannabinol, tetrahydrocannabinolic acid, and cannabigerol) in oil-in-water cosmetic emulsions. The sample extraction is based on dispersing the sample in isopropanol, followed by solid-phase extraction using Bond Elut Plexa PAX cartridge. The viability of this method is demonstrated by comparing matrix effects in samples subjected to solid-phase extraction (0‒11% suppression of cannabidiol ionization) to samples extracted without additional purification steps (0‒84% ionization suppression of cannabidiol ionization). The limit of quantification is determined at 0.1 mg/g and the calibration is employed in the range of 0.1‒50 mg/g for cannabidiol and 0.1‒10 mg/g for all other analytes. Finally, 36 real cosmetic samples from the Czech market were analyzed. Of these, 14 indicated the amount of CBD on the label but only five (36%) were accurate, i.e., within 90‒110% of the labeled amount, and a considerable amount of THC (0.16 ± 0.01 mg/g) was found in one sample. These findings contribute to the cumulating evidence that cannabidiol-based consumer products are often mislabeled and highlight the importance of better regulatory compliance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ANALYTICAL AND BIOANALYTICAL CHEMISTRY

ISSN

1618-2642

e-ISSN

1618-2650

Svazek periodika

417

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

1153-1163

Kód UT WoS článku

001390273900001

EID výsledku v databázi Scopus

2-s2.0-85214120934