A discrete model of signal transmission in an epithelial layer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F03%3A00007560" target="_blank" >RIV/60461373:22340/03:00007560 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A discrete model of signal transmission in an epithelial layer

Popis výsledku v původním jazyce

Pattern formation and other processes (cancer, programmed cell death etc.) in epithelial layers heavily relies on cell communication by secreted ligands - growth factors. These, mostly extracellular, ligands activate or inhibit intracellular metabolic pathways that control secretion of the growth factors. The released growth factors can diffuse through the extracellular space and interact with receptors on a cell surface (autocrine and paracrine signaling). The resulting combination of ligands bound onreceptors and their concentration determinates the cell development. This contribution is devoted to the mathematical analysis of a positive feedback in cell-cell interactions (ligand-receptor interaction complex formation activation of ligand release ligand transport ligand-receptor interaction). A mathematical model of the cell-cell signaling was proposed. The model is relevant to the physiology of epithelial layers and to a number of in-vitro experiments. The model analysis predicts e

Název v anglickém jazyce

A discrete model of signal transmission in an epithelial layer

Popis výsledku anglicky

Pattern formation and other processes (cancer, programmed cell death etc.) in epithelial layers heavily relies on cell communication by secreted ligands - growth factors. These, mostly extracellular, ligands activate or inhibit intracellular metabolic pathways that control secretion of the growth factors. The released growth factors can diffuse through the extracellular space and interact with receptors on a cell surface (autocrine and paracrine signaling). The resulting combination of ligands bound onreceptors and their concentration determinates the cell development. This contribution is devoted to the mathematical analysis of a positive feedback in cell-cell interactions (ligand-receptor interaction complex formation activation of ligand release ligand transport ligand-receptor interaction). A mathematical model of the cell-cell signaling was proposed. The model is relevant to the physiology of epithelial layers and to a number of in-vitro experiments. The model analysis predicts e

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 30th International Conference of Slovak Society of Chemical Engineering, Tatranské Matliare 26.- 30.5.2003, CD-ROM

ISBN

80-227-1889-0

ISSN

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e-ISSN

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Počet stran výsledku

9

Strana od-do

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Název nakladatele

Slovak University of Technology

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare, Slovakia

Datum konání akce

26. 5. 2003

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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