In vitro interaction of macrocyclic photosensitizers with intact mitochondria: a spectroscopic study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F03%3A00007579" target="_blank" >RIV/60461373:22340/03:00007579 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/03:00007579

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

In vitro interaction of macrocyclic photosensitizers with intact mitochondria: a spectroscopic study

Popis výsledku v původním jazyce

Six water-soluble macrocyclic photosensitizers, the members of two groups of expanded porphyrins (metallotexaphyrins and free-base sapphyrins) containing hydrophilic substituents and meso-tetra(4-sulfonatophenyl)-porphyrin, were tested by UV-Vis absorption and resonance Raman spectroscopy in the in vitro nibding experiments with intact mitochondria isolated form swine liver. Studied macrocycles showed markedly differenrt affinity to mitochondria. The highest uptake was observed for sapphyrin-sugar conjugate and metal-lotexaphirins. Sapphirin-polyamine conjugates exhibit something less affinity to mitochondria, while the porphyrin of anionic character showed very low mitochondrial uptake. Obtained spectroscopic results confirm that the binding process altered the self-aggregatio degree fo expanded porphyrins.

Název v anglickém jazyce

In vitro interaction of macrocyclic photosensitizers with intact mitochondria: a spectroscopic study

Popis výsledku anglicky

Six water-soluble macrocyclic photosensitizers, the members of two groups of expanded porphyrins (metallotexaphyrins and free-base sapphyrins) containing hydrophilic substituents and meso-tetra(4-sulfonatophenyl)-porphyrin, were tested by UV-Vis absorption and resonance Raman spectroscopy in the in vitro nibding experiments with intact mitochondria isolated form swine liver. Studied macrocycles showed markedly differenrt affinity to mitochondria. The highest uptake was observed for sapphyrin-sugar conjugate and metal-lotexaphirins. Sapphirin-polyamine conjugates exhibit something less affinity to mitochondria, while the porphyrin of anionic character showed very low mitochondrial uptake. Obtained spectroscopic results confirm that the binding process altered the self-aggregatio degree fo expanded porphyrins.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochimica and Biophysica Acta (BBA) - general subjects

ISSN

0006-3002

e-ISSN

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Svazek periodika

1620

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

85-96

Kód UT WoS článku

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EID výsledku v databázi Scopus

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