Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F11%3A43892159" target="_blank" >RIV/60461373:22340/11:43892159 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.compchemeng.2010.07.008" target="_blank" >http://dx.doi.org/10.1016/j.compchemeng.2010.07.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.compchemeng.2010.07.008" target="_blank" >10.1016/j.compchemeng.2010.07.008</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution
Popis výsledku v původním jazyce
A computer model was developed with the objective of modelling pharmaceutical tablet dissolution with non-swelling excipients. The model, which allows the explicit description of the tablets heterogeneous microstructure, was verified using Fourier Transform Infrared (FTIR) spectroscopic imaging and UV-visible spectroscopy. Two parametric studies were conducted using the model for binary tablets. One investigated the effect of particle size and tablet composition on component release times and the otherstudied the effect of changing the diffusivity and solubility of one component on the release times of both. Tablets containing Polyethylene Glycol (PEG) 4000 and nicotinamide were used in the experiments. Physical properties of pure components were obtained from literature and also experiments using tablets containing 100% and 10% (w/w) nicotinamide. The model was then used to predict the dissolution of a tablet containing 40% (w/w) nicotinamide which matched the experiment with a mean
Název v anglickém jazyce
Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution
Popis výsledku anglicky
A computer model was developed with the objective of modelling pharmaceutical tablet dissolution with non-swelling excipients. The model, which allows the explicit description of the tablets heterogeneous microstructure, was verified using Fourier Transform Infrared (FTIR) spectroscopic imaging and UV-visible spectroscopy. Two parametric studies were conducted using the model for binary tablets. One investigated the effect of particle size and tablet composition on component release times and the otherstudied the effect of changing the diffusivity and solubility of one component on the release times of both. Tablets containing Polyethylene Glycol (PEG) 4000 and nicotinamide were used in the experiments. Physical properties of pure components were obtained from literature and also experiments using tablets containing 100% and 10% (w/w) nicotinamide. The model was then used to predict the dissolution of a tablet containing 40% (w/w) nicotinamide which matched the experiment with a mean
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CI - Průmyslová chemie a chemické inženýrství
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
R - Projekt Ramcoveho programu EK
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
COMPUTERS & CHEMICAL ENGINEERING
ISSN
0098-1354
e-ISSN
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Svazek periodika
35
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
12
Strana od-do
1328-1339
Kód UT WoS článku
000292093700015
EID výsledku v databázi Scopus
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