Formulation design space analysis for drug release from swelling polymer tablets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895522" target="_blank" >RIV/60461373:22340/13:43895522 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.powtec.2012.02.027" target="_blank" >http://dx.doi.org/10.1016/j.powtec.2012.02.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2012.02.027" target="_blank" >10.1016/j.powtec.2012.02.027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Formulation design space analysis for drug release from swelling polymer tablets

Popis výsledku v původním jazyce

A model is presented which can be used to simulate polymer swelling and drug release from tablets using a combination of the Discrete Element Method (DEM) and solving mass transfer over an unstructured grid formed by the DEM elements. This work extends arecently developed single-component swelling and dissolution model by incorporating an extra component (drug) that can be either homogeneously or heterogeneously dispersed within the tablet. Parametric studies were conducted on some of the key parameters which affect drug release, namely the drug distribution, maximum swelling ratio of the polymer and the drug-polymer diffusivity dependence. The drug heterogeneity study showed that burst release (i.e. dose-dumping) increased as drug loading increased since the polymer could not form a gel layer to surround the tablet but the time taken for 99% drug release was not significantly different when compared to the homogeneous case. The maximum swelling ratio study showed that drug release co

Název v anglickém jazyce

Formulation design space analysis for drug release from swelling polymer tablets

Popis výsledku anglicky

A model is presented which can be used to simulate polymer swelling and drug release from tablets using a combination of the Discrete Element Method (DEM) and solving mass transfer over an unstructured grid formed by the DEM elements. This work extends arecently developed single-component swelling and dissolution model by incorporating an extra component (drug) that can be either homogeneously or heterogeneously dispersed within the tablet. Parametric studies were conducted on some of the key parameters which affect drug release, namely the drug distribution, maximum swelling ratio of the polymer and the drug-polymer diffusivity dependence. The drug heterogeneity study showed that burst release (i.e. dose-dumping) increased as drug loading increased since the polymer could not form a gel layer to surround the tablet but the time taken for 99% drug release was not significantly different when compared to the homogeneous case. The maximum swelling ratio study showed that drug release co

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder Technology

ISSN

0032-5910

e-ISSN

—

Svazek periodika

236

Číslo periodika v rámci svazku

February 2013

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

179-187

Kód UT WoS článku

000316516300022

EID výsledku v databázi Scopus

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