DEM simulation of drug release from structurally heterogeneous swelling tablets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895513" target="_blank" >RIV/60461373:22340/13:43895513 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.039" target="_blank" >http://dx.doi.org/10.1016/j.powtec.2012.12.039</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.039" target="_blank" >10.1016/j.powtec.2012.12.039</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DEM simulation of drug release from structurally heterogeneous swelling tablets

Popis výsledku v původním jazyce

The Discrete Element Method (DEM) was used to generate an unstructured mesh over which mass transfer equations were solved. This has been applied to model swelling and drug release from pharmaceutical tablets and is useful for studying in vitro?in vivo correlation (IVIVC) and virtual formulation development. Parametric studies were conducted into the effect of tablet shape and aspect ratio, polymer properties and shell thickness, and boundary conditions around the tablet on drug release time (t90), theshape of the release curve and tablet evolution. The first study showed that drug release from tablets containing the same mass of polymer and drug but having different shapes and aspect ratios was only dependent on aspect ratio and not tablet shape. Investigations into polymer properties and coating thickness showed that drug release is fastest for moderately swelling polymers and that similar t90 can be obtained for different combinations of parameters. The final study into different b

Název v anglickém jazyce

DEM simulation of drug release from structurally heterogeneous swelling tablets

Popis výsledku anglicky

The Discrete Element Method (DEM) was used to generate an unstructured mesh over which mass transfer equations were solved. This has been applied to model swelling and drug release from pharmaceutical tablets and is useful for studying in vitro?in vivo correlation (IVIVC) and virtual formulation development. Parametric studies were conducted into the effect of tablet shape and aspect ratio, polymer properties and shell thickness, and boundary conditions around the tablet on drug release time (t90), theshape of the release curve and tablet evolution. The first study showed that drug release from tablets containing the same mass of polymer and drug but having different shapes and aspect ratios was only dependent on aspect ratio and not tablet shape. Investigations into polymer properties and coating thickness showed that drug release is fastest for moderately swelling polymers and that similar t90 can be obtained for different combinations of parameters. The final study into different b

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

—

Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder Technology

ISSN

0032-5910

e-ISSN

—

Svazek periodika

248

Číslo periodika v rámci svazku

November 2013

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

68-76

Kód UT WoS článku

000325843400007

EID výsledku v databázi Scopus

—